Table 2 Net benefit of RYR preparations in lipid profile in placebo-controlled trials

TC levels (mmol/L)

Cholestin

42

6.47 (0.78)

5.43 (0.80)

-1.04 (-1.38 to -0.70)

-16%

< 0.00001

Placebo

41

6.59 (0.75)

6.47 (0.93)

-0.12 (-0.49 to 0.25)

-2%

0.52

30

6.68 (0.98)

5.31 (0.84)

-1.37 (-1.83 to -0.91)

-21%

33

5.81 (0.63)

4.26 (0.63)

-1.55 (-1.85 to -1.25)

-27%

Xuezhikang

101

7.30 (1.40)

5.90 (1.40)

-1.40 (-1.79 to -1.01)

-19%

30

5.65 (1.31)

3.16 (1.31)

-2.49 (-3.15 to -1.83)

-44%

Subtotal: 194

-1.63 (-2.00 to -1.26)

< 0.00001

28

6.72 (0.97)

6.43 (0.93)

-0.29 (-0.79 to 0.21)

-4%

30

5.84 (0.67)

4.94 (0.67)

-0.90 (-1.24 to -0.56)

-15%

Placebo

51

6.80 (1.40)

6.70 (1.40)

-0.10 (-0.64 to 0.44)

-1%

20

5.55 (1.02)

4.95 (1.02)

-0.60 (-1.23 to 0.03)

-11%

Subtotal: 129

-0.50 (-0.90 to -0.11)

0.01

9

5.90 (0.95)

4.94 (0.65)

-0.96 (-1.71 to -0.21)

-16%

Zhibituo

30

6.70 (1.10)

5.80 (0.90)

-0.90 (-1.41 to -0.39)

-13%

104

7.10 (1.70)

5.60 (1.30)

-1.50 (-1.91 to -1.09)

-21%

Subtotal: 143

-1.17 (-1.59 to -0.74)

< 0.00001

9

5.83 (0.57)

5.56 (0.53)

-0.27 (-0.78 to 0.24)

-5%

Placebo

30

6.70 (1.50)

6.40 (1.30)

-0.30 (-1.01 to 0.41)

-4%

101

6.00 (1.80)

6.50 (0.70)

0.50 (0.12 to 0.88)

8%

Subtotal: 140

0.02 (-0.56 to 0.60)

0.95

TG levels (mmol/L)

Cholestin

42

1.50 (0.54)

1.40 (0.50)

-0.10 (-0.32 to 0.12)

-7%

0.38

Placebo

41

1.61 (0.52)

1.65 (0.53)

0.04 (-0.19 to 0.27)

2%

30

2.84 (0.57)

2.38 (0.62)

-0.46 (-0.76 to -0.16)

-16%

33

2.10 (0.92)

1.82 (0.92)

-0.28 (-0.72 to 0.16)

-13%

Xuezhikang

101

3.60 (2.40)

2.30 (1.60)

-1.30 (-1.86 to -0.74)

-36%

30

2.62 (0.58)

1.47 (0.58)

-1.15 (-1.44 to -0.86)

-44%

Subtotal: 194

-0.78 (-1.26 to -0.31)

0.001

28

2.74 (0.73)

2.57 (0.69)

-0.17 (-0.54 to 0.20)

-6%

Placebo

30

2.14 (0.94)

1.91 (0.94) 3.00 (1.60)

-0.23 (-0.71 to 0.25) -0.30 (-0.92 to 0.32)

-11%

51

3.30 (1.60)

3.00 (1.60)

-0.30 (-0.92 to 0.32)

-9%

20

2.50 (0.50)

2.11 (0.50)

-0.39 (-0.70 to -0.08)

-16%

Subtotal: 129

-0.29 (-0.49 to -0.09)

0.005

13

2.46 (1.23)

1.79 (0.57)

-0.67 (-1.41 to 0.07)

-27%

Zhibituo

30

3.40 (0.90)

2.10 (1.10)

-1.30 (-1.81 to -0.79)

-38%

104

3.40 (1.50)

2.30 (1.30)

-1.10 (-1.48 to -0.72)

-32%

Subtotal: 147

-1.10 (-1.38 to -0.82)

< 0.00001

9

2.56 (0.88)

2.36 (0.64)

-0.20 (-0.91 to 0.51)

-8%

30

3.40 (1.10)

3.10 (1.20)

-0.30 (-0.88 to 0.28)

-9%

Placebo

101

3.10 (0.40)

2.50 (1.40)

-0.60 (-0.88 to -0.32)

-19%

Subtotal: 140

-0.50 (-0.74 to -0.26)

< 0.0001

LDL-C levels (mmol/L)

Cholestin

42

4.47 (0.70)

3.49 (0.70)

-0.98 (-1.28 to -0.68)

-22%

< 0.00001

Placebo

41

4.65 (0.78)

4.53 (0.85)

-0.12 (-0.47 to 0.23)

-3%

0.51

30

3.94 (0.82)

2.83 (0.88)

-1.11 (-1.54 to -0.68)

-28%

33

4.13 (0.52)

2.80 (0.52)

-1.33 (-1.58 to -1.08)

-32%

Xuezhikang

101

4.80 (1.60)

3.50 (1.40)

-1.30 (-1.71 to -0.89)

-27%

30

3.00 (1.03)

2.10 (1.03)

-0.90 (-1.42 to -0.38)

-30%

Subtotal: 194

-1.23 (-1.41 to -1.05)

<0.00001

28

4.13 (0.94)

4.01 (0.86)

-0.12 (-0.59 to 0.35)

-3%

30

4.24 (0.53)

3.41 (0.53)

-0.83 (-1.10 to -0.56)

-20%

Placebo

51

4.20 (1.60)

4.30 (1.60)

0.10 (-0.52 to 0.72)

2%

20

3.19 (0.87)

2.70 (0.87)

-0.49 (-1.03 to 0.05)

-15%

Subtotal: 129

-0.38 (-0.83 to 0.07)

0.10

Zhibituo

104

3.70 (1.60)

3.50 (1.40)

-0.20 (-0.61 to 0.21)

-5%

0.34

Placebo

101

3.70 (1.20)

3.70 (1.00)

0.00 (-0.30 to 0.30)

0%

1.00

HDL-C levels (mmol/L)

Cholestin

42

1.29 (0.34)

1.29 (0.36)

0.00 (-0.15 to 0.15)

0%

1.00

Placebo

41

1.19 (0.26)

1.19 (0.28)

0.00 (-0.12 to 0.12)

0%

1.00

30

1.50 (0.46)

1.67 (0.54)

0.17 (-0.08 to 0.42)

11%

33

1.37 (0.21)

1.16 (0.21)

-0.21 (-0.31 to -0.11)

-15%

Xuezhikang

101

1.20 (0.40)

1.40 (0.30)

0.20 (0.10 to 0.30)

17%

30

1.20 (0.21)

1.22 (0.21)

0.02 (-0.09 to 0.13)

2%

Subtotal: 194

0.04 (-0.17 to 0.24)

0.73

28

1.57 (0.69)

1.53 (0.32)

-0.04 (-0.32 to 0.24)

-3%

30

1.36 (0.24)

1.13 (0.24)

-0.23 (-0.35 to -0.11)

-17%

51

1.30 (0.40)

1.30 (0.30)

0.00 (-0.14 to 0.14)

0%

Placebo

20

1.22 (0.25)

1.00 (0.25)

-0.22 (-0.37 to -0.07)

-18%

Subtotal: 129

-0.13 (-0.26 to -0.01)

0.04

13

0.89 (0.41)

1.09 (0.41)

0.20 (-0.12 to 0.52)

22%

30

1.08 (0.11)

1.31 (0.17)

0.23 (0.16 to 0.30)

21%

Zhibituo

104

0.85 (0.14)

0.98 (0.26)

0.13 (0.07 to 0.19)

15%

Subtotal: 147

0.18 (0.10 to 0.26)

< 0.0001

13

0.92 (0.19)

0.90 (0.17)

-0.02 (-0.16 to 0.12)

-2%

30

0.99 (0.20)

1.02 (0.28)

0.03 (-0.09 to 0.15)

3%

Placebo

101

0.89 (0.13)

0.80 (0.30)

-0.09 (-0.15 to -0.03)

-10%

Subtotal: 144

-0.04 (-0.12 to 0.03)

0.26