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Table 3 Post-treatment total cholesterol levels (mmol/L) in randomized controlled trials

From: Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials

Interventions No. of trials [references] No. of participants Weighted mean difference (95% confidence interval) P value
RYR vs. no intervention/placebo     
Zhibituo vs. no intervention 2 [22, 23] 112 -1.27 (-1.50 to -1.05) < 0.00001
RYR supplement vs. placebo 1 [7] 83 -1.04 (-1.41 to -0.67) < 0.00001
Xuezhikang vs. placebo 4 [8, 24–26] 323 -1.04 (-1.46 to -0.62)* < 0.00001
Zhibituo vs. placebo 3 [27–29] 283 -0.80 (-1.03 to -0.57) < 0.00001
RYR vs. statins     
Xuezhikang vs. simvastatin 15 [6, 30–43] 1455 0.05 (-0.27 to 0.37)* 0.76
Xuezhikang vs. pravastatin 7 [44–50] 594 - 0.20 (- 0.47 to 0.06)* 0.14
Xuezhikang vs. lovastatin 3 [51–53] 174 -0.05 (-0.27 to 0.18) 0.69
Xuezhikang vs. atorvastatin 1 [54] 60 -0.16 (-0.58 to 0.26) 0.46
Xuezhikang vs. fluvastatin 1 [55] 118 0.48 (0.24 to 0.72) 0.0001
Zhibituo vs. simvastatin 9 [32, 56–63] 728 0.11 (-0.03 to 0.25) 0.14
Zhibituo vs. provastatin 1 [22] 62 0.05 (-0.20 to 0.30) 0.70
Zhibituo vs. lovastatin 1 [57] 45 -0.11 (-0.48 to 0.26) 0.56
RYR vs. non-statin drugs     
Xuezhikang vs. inositol nicotinate 7 [65–71] 624 -0.56 (-0.81 to -0.31)* < 0.0001
Xuezhikang vs. fenofibrate 5 [32, 73–76] 337 -0.13 (-0.46 to 0.20)* 0.44
Xuezhikang vs. gemfibrozil 3 [77–79] 156 -0.43 (-1.52 to 0.65)* 0.43
Xuezhikang vs. fish oils 2 [80, 81] 116 -0.81 (-1.11 to -0.50) < 0.00001
Xuezhikang vs. alginic sodium diester 1 [84] 60 -1.08 (-1.38 to -0.78) < 0.00001
Xuezhikang vs. conjugated estrogens 1 [85] 44 -0.87 (-1.20 to -0.54) < 0.00001
Xuezhikang vs. elastase 1 [86] 107 -0.10 (-0.49 to 0.29) 0.61
Xuezhikang vs. biphenalbid 1 [87] 64 0.12 (-0.31 to 0.55) 0.59
Zhibituo vs. inositol nicotinate 8 [88–95] 608 -0.73 (-1.13 to -0.33)* 0.0004
Zhibituo vs. fish oils 6 [97–102] 491 -0.76 (-1.04 to -0.49)* < 0.00001
Zhibituo vs. fenofibrate 2 [32, 104] 248 0.31 (0.04 to 0.59) 0.02
RYR versus RYR     
Xuezhikang vs. Zhibituo 7 [32, 106–111] 701 -0.03 (-0.25 to 0.20)* 0.82
  1. * Random effects model