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Table 6 Post-treatment high-density lipoprotein cholesterol levels (mmol/L) in randomized controlled trials

From: Chinese red yeast rice (Monascus purpureus) for primary hyperlipidemia: a meta-analysis of randomized controlled trials

Interventions No. of trials [references] No. of participants Weighted mean difference its (95% confidence interval) P value
RYR vs. no intervention/placebo     
Zhibituo vs. no intervention 1 [22] 62 0.21 (0.04 to 0.38) 0.02
RYR supplement vs. placebo 1 [7] 83 0.10 (-0.04 to 0.24) 0.16
Xuezhikang vs. placebo 4 [8, 24–26] 323 0.11 (0.05 to 0.17) 0.0008
Zhibituo vs. placebo 3 [27–29] 291 0.21 (0.15 to 0.27) < 0.00001
RYR vs. statins     
Xuezhikang vs. simvastatin 14 [6, 30–34, 36–43] 1277 0.06 (-0.11 to 0.22)* 0.49
Xuezhikang vs. pravastatin 7 [44–50] 587 -0.01 (-0.06 to 0.03) 0.51
Xuezhikang vs. lovastatin 3 [51–53] 152 0.06 (0.00 to 0.11) 0.05
Xuezhikang vs. atorvastatin 1 [54] 60 0.01 (-0.17 to 0.19) 0.91
Xuezhikang vs. fluvastatin 1 [55] 118 -0.02 (-0.1 0 to 0.06) 0.62
Zhibituo vs. simvastatin 9 [32, 56–63] 666 -0.07 (-0.12 to -0.03) 0.0009
Zhibituo vs. provastatin 1 [22] 62 -0.02 (-0.22 to 0.18) 0.85
Zhibituo vs. lovastatin 1 [57] 45 -0.07 (-0.23 to 0.09) 0.39
RYR vs. non-statin drugs     
Xuezhikang vs. inositol nicotinate 7 [65–71] 608 0.17 (0.06 to 0.28)* 0.002
Xuezhikang vs. fenofibrate 4 [32, 73, 74, 76] 257 0.03 (-0.06 to 0.13) 0.49
Xuezhikang vs. gemfibrozil 2 [77, 79] 108 -0.03 (-0.3 5 to 0.28) 0.83
Xuezhikang vs. fish oils 2 [80, 81] 70 0.17 (0.09 to 0.25) < 0.0001
Xuezhikang vs. alginic sodium diester 1 [84] 60 0.86 (0.75 to 0.97) < 0.00001
Xuezhikang vs. conjugated estrogens 1 [85] 44 0.00 (-0.09 to 0.09) 1.00
Xuezhikang vs. elastase 1 [86] 107 0.20 (0.10 to 0.30) < 0.0001
Xuezhikang vs. biphenalbid 1 [87] 64 0.25 (0.11 to 0.39) 0.0003
Zhibituo vs. inositol nicotinate 6 [89–91, 93–95] 422 0.18 (0.09 to 0.27)* < 0.0001
Zhibituo vs. fish oils 6 [97–102] 400 0.14 (0.06 to 0.23)* 0.001
Zhibituo vs. fenofibrate 2 [32, 104] 248 -0.13 (-0.37 to 0.11) 0.28
RYR vs. RYR     
Xuezhikang vs. Zhibituo 7 [32, 106–111] 627 0.04 (-0.02 to 0.11)* 0.20
  1. * Random effects model