Table 6 Post-treatment high-density lipoprotein cholesterol levels (mmol/L) in randomized controlled trials
Interventions | No. of trials [references] | No. of participants | Weighted mean difference its (95% confidence interval) | P value |
|---|---|---|---|---|
RYR vs. no intervention/placebo | Â | Â | Â | Â |
Zhibituo vs. no intervention | 1 [22] | 62 | 0.21 (0.04 to 0.38) | 0.02 |
RYR supplement vs. placebo | 1 [7] | 83 | 0.10 (-0.04 to 0.24) | 0.16 |
Xuezhikang vs. placebo | 4 [8, 24–26] | 323 | 0.11 (0.05 to 0.17) | 0.0008 |
Zhibituo vs. placebo | 3 [27–29] | 291 | 0.21 (0.15 to 0.27) | < 0.00001 |
RYR vs. statins | Â | Â | Â | Â |
Xuezhikang vs. simvastatin | 14 [6, 30–34, 36–43] | 1277 | 0.06 (-0.11 to 0.22)* | 0.49 |
Xuezhikang vs. pravastatin | 7 [44–50] | 587 | -0.01 (-0.06 to 0.03) | 0.51 |
Xuezhikang vs. lovastatin | 3 [51–53] | 152 | 0.06 (0.00 to 0.11) | 0.05 |
Xuezhikang vs. atorvastatin | 1 [54] | 60 | 0.01 (-0.17 to 0.19) | 0.91 |
Xuezhikang vs. fluvastatin | 1 [55] | 118 | -0.02 (-0.1 0 to 0.06) | 0.62 |
Zhibituo vs. simvastatin | 9 [32, 56–63] | 666 | -0.07 (-0.12 to -0.03) | 0.0009 |
Zhibituo vs. provastatin | 1 [22] | 62 | -0.02 (-0.22 to 0.18) | 0.85 |
Zhibituo vs. lovastatin | 1 [57] | 45 | -0.07 (-0.23 to 0.09) | 0.39 |
RYR vs. non-statin drugs | Â | Â | Â | Â |
Xuezhikang vs. inositol nicotinate | 7 [65–71] | 608 | 0.17 (0.06 to 0.28)* | 0.002 |
Xuezhikang vs. fenofibrate | 4 [32, 73, 74, 76] | 257 | 0.03 (-0.06 to 0.13) | 0.49 |
Xuezhikang vs. gemfibrozil | 2 [77, 79] | 108 | -0.03 (-0.3 5 to 0.28) | 0.83 |
Xuezhikang vs. fish oils | 2 [80, 81] | 70 | 0.17 (0.09 to 0.25) | < 0.0001 |
Xuezhikang vs. alginic sodium diester | 1 [84] | 60 | 0.86 (0.75 to 0.97) | < 0.00001 |
Xuezhikang vs. conjugated estrogens | 1 [85] | 44 | 0.00 (-0.09 to 0.09) | 1.00 |
Xuezhikang vs. elastase | 1 [86] | 107 | 0.20 (0.10 to 0.30) | < 0.0001 |
Xuezhikang vs. biphenalbid | 1 [87] | 64 | 0.25 (0.11 to 0.39) | 0.0003 |
Zhibituo vs. inositol nicotinate | 6 [89–91, 93–95] | 422 | 0.18 (0.09 to 0.27)* | < 0.0001 |
Zhibituo vs. fish oils | 6 [97–102] | 400 | 0.14 (0.06 to 0.23)* | 0.001 |
Zhibituo vs. fenofibrate | 2 [32, 104] | 248 | -0.13 (-0.37 to 0.11) | 0.28 |
RYR vs. RYR | Â | Â | Â | Â |
Xuezhikang vs. Zhibituo | 7 [32, 106–111] | 627 | 0.04 (-0.02 to 0.11)* | 0.20 |