Table 1 Biological evaluation of DBT (in vitro studies)
Findings | Model | Treatment | Reference |
|---|---|---|---|
The 5:1 ratio DBT showed stronger effects in stimulating MG-63 cell proliferation and induced ALP activity to the highest level among all groups. | Cultured human MG-63 osteosarcoma cells | DBT of various ratios of RA and RAS, compared with β-estradiol and negative control | Dong et al. [19] |
The 5:1 ratio DBT showed the strongest effect in inducing the estrogen-driven promoter activity than RA, RAS alone or the extracts of other ratios. | Cultured MCF-7 cells | DBT of various ratios of RA and RAS, compared with β-estradiol and negative control | Dong et al. [19] |
The ratios 5:1 and 7:1 DBT showed higher levels of activity in preventing platelet aggregation. | ADP induced-platelet aggregation in blood from adult New Zealand white rabbits | DBT of various ratios of RA and RAS, compared with ticlopidine and negative control | Dong et al. [19] |
DBT induced cell proliferation, interleukin-2 secretion and the phosphorylation of extracellular signal-regulated kinase (ERK1/2) in cultured T-lymphocytes. The 5:1 ratio DBT showed the strongest immuno-modulatory effects. | Cultured T-lymphocytes and macrophages | DBT of various ratios of RA and RAS, compared with PHA, PMA, Zymosan A and negative control | Gao et al. [23] |