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Table 1 Biological evaluation of DBT (in vitro studies)

From: Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae

Findings Model Treatment Reference
The 5:1 ratio DBT showed stronger effects in stimulating MG-63 cell proliferation and induced ALP activity to the highest level among all groups. Cultured human MG-63 osteosarcoma cells DBT of various ratios of RA and RAS, compared with β-estradiol and negative control Dong et al. [19]
The 5:1 ratio DBT showed the strongest effect in inducing the estrogen-driven promoter activity than RA, RAS alone or the extracts of other ratios. Cultured MCF-7 cells DBT of various ratios of RA and RAS, compared with β-estradiol and negative control Dong et al. [19]
The ratios 5:1 and 7:1 DBT showed higher levels of activity in preventing platelet aggregation. ADP induced-platelet aggregation in blood from adult New Zealand white rabbits DBT of various ratios of RA and RAS, compared with ticlopidine and negative control Dong et al. [19]
DBT induced cell proliferation, interleukin-2 secretion and the phosphorylation of extracellular signal-regulated kinase (ERK1/2) in cultured T-lymphocytes. The 5:1 ratio DBT showed the strongest immuno-modulatory effects. Cultured T-lymphocytes and macrophages DBT of various ratios of RA and RAS, compared with PHA, PMA, Zymosan A and negative control Gao et al. [23]