Skip to main content

Advertisement

Table 2 Biological evaluation of DBT (in vivo studies)

From: Verification of the formulation and efficacy of Danggui Buxue Tang (a decoction of Radix Astragali and Radix Angelicae Sinensis): an exemplifying systematic approach to revealing the complexity of Chinese herbal medicine formulae

Findings Model Treatment Reference
DBT had significantly higher RBC and Hb levels in both normal and anemic mice than those in RA, RAS and control. Kunming mice, male, RBC, Hb Normal mice in 4 groups: RA, RAS, DBT and control; Anemic mice in 4 groups: RA, RAS, DBT and control Wu BC et al. [24]
DBT was the most effective decoction in triggering immune responses. Kunming mice, RBC, Hb, WBC, Plt, reticulocyte, nucleated cells of bone cavity, weight of pancreas and thymus Mice in 5 groups: RA, RAS, DBT, RA+RAS (1:1) and control Li YK et al. [25]
DBT alleviated cardiac injury in ischemia reperfusion. Wister rats (male), amplitudes of LVSP and ± dp/dtmax, arterial pressure, Na+-K+-ATP activity, level of MDA production, cAMP content Rats in myocardial ischemia reperfusion injury; i.v. Wu DZ et al. [26]
DBT increased the levels of RBC, WBC, and BMNC. Some DBT promoted the proliferation of BMNC and increased the level of CFU-Mix. Kunming mice, ICR mice, Balb/c mice, RBC, WBC, reticulocytes and BMNC Mice in 4 groups: normal, model, DBT without polysaccharides, DBT with polysaccharides Ning L et al. [27]
DBT enhanced myocardial mitochondria and red blood cell glutathione status. Rats, myocardial mitochondrial status, RBC glutathione status Rats in 5 groups: RA, RAS, DBT, RA + RAS (not boiled together) and control; orally administered Mak DH et al. [28]
DBT inhibited growth of GM-CFU, while the decoction-containing serum promoted growth of GM-CFU. Kunming mice, GM-CFU DBT was administered orally; serum collected from abdominal aorta was added to an in vitro cultivating system of mouse hematopoietic progenitor cells. Zhang YH et al. [29]
The decoction-containing serum showed promoting actions to CFU-E. RA+RAS (5:1) was 97.81% stronger than RA+RAS (1:1). Kunming mice, CFU-E DBT was administered orally; serum collected from abdominal aorta was added to an in vitro cultivating system of mouse hematopoietic progenitor cells. Zhang YH et al. [30]