Recent advances in the investigation of curcuminoids

Chinese Medicine

Table 2 Anti-oxidant activity data of curcumin derivatives

Compound	R₁	R₂	R₃	Lipid peroxidation inhibition IC₅₀ (μM)	DPPH scavenging IC₅₀ (μM)	ABTS scavenging TEAC
Compound	R₁	R₂	R₃	Lipid peroxidation inhibition IC₅₀ (μM)	DPPH scavenging IC₅₀ (μM)	3 min	9 min	15 min
2	OCH₃	OH	H	1.30	20.02	2.61	3.09	3.37
3	H	OH	H	2.19	32.08	3.04	4.31	4.96
9	structure formula 9 above			1.83	18.22	2.08	2.37	2.52
10	OCH₃	OAc	H	1.85	NA	1.33	2.01	2.33
12	H	H	H	NA	>250	1.57	2.78	3.36
14	OCH₃	OCH₃	OCH₃	15.32	NA	1.90	2.98	3.43
15	CH₃	OH	CH₃	0.63	21.75	0.89	1.13	1.28
20	H	OCH₃	H	NA	>250	2.05	2.04	2.14
21	H	CH₃	H	NA	>250	0.67	1.52	1.96
22	OCH₃	OCH₃	H	NA	>250	1.86	2.49	2.67
23	t-C₄H₉	OH	t-C₄H₉	6.48	23.72	0.81	0.96	1.07
33	OC₂H₅	OH	H	1.11	30.32	2.36	3.07	3.32
34	H	SCH₃	H	NA	NA below 90	1.09	ND	ND

IC₅₀ is the concentration required for 50% inhibition of lipid peroxidation or scavenging of DPPH radical. TEAC is the trolox equivalent anti-oxidation capacity, which is defined as the mM concentration of a trolox solution having the antioxidant capacity equivalent to a 1.0 mM solution of the substance under investigation.
NA: not active
ND: not determined.

ISSN: 1749-8546