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Table 2 Bax, bcl-2 and caspase-3 expression (in IOD) in tumor tissues of LLC in mice

From: In vitro and in vivo antitumor effects of acetylshikonin isolated from Arnebia euchroma (Royle) Johnst (Ruanzicao) cell suspension cultures

    

Percentiles

Group

(n = 10)

Dose

(mg/kg)

Mean

SD

25th

50th (median)

75th

Bax

      

   Control

-

13633

2531

11244

13712

15634

Acetylshikonin

2 × 6

48678

2534

46432

48519***

51406

 

1 × 6

28502

5064

23628

30232***

33082

 

0.5 × 6

21844

4882

16476

22988**

26209

bcl-2

      

   Control

-

19859

2822

17076

20065

22292

Acetylshikonin

2 × 6

8126

1115

7267

7926***

8596

 

1 × 6

11171

1459

9916

10814***

12478

 

0.5 × 6

15652

1724

14447

15234**

16742

Bax/bcl-2

      

   Control

-

0.70

0.17

0.58

0.74

0.79

Acetylshikonin

2 × 6

6.11

0.92

5.54

6.05***

6.26

 

1 × 6

2.56

0.36

2.34

2.47***

2.77

 

0.5 × 6

1.41

0.32

1.14

1.29**

1.77

Caspase-3

      

   Control

-

12746

3155

10359

12019

13714

Acetylshikonin

2 × 6

31618

3155

29396

31226***

33530

 

1 × 6

22653

4647

18898

21756***

25119

 

0.5 × 6

13582

3737

10009

13186

17705

  1. ** P < 0.01, *** P < 0.001, vs. control