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Table 2 Anti-fibrosis effect of composite formulae

From: Chinese medicines as a resource for liver fibrosis treatment

Composite formulae and major references

Pharmacological actions and clinical indications

Compositions of formulae

Yinchenhao Tang [69–78]

Induce HSCs apoptosis, inhibit HSCs activation, reduce collagen deposition and α-SMA and decrease the serum level of HA, apply to postoperative biliary atresia patients and icteric patients with cirrhosis

Herba Artemisiae Scopariae, Radix et Rhizoma Rhei, Fructus Gardeniae

Xiao Chaihu Tang[79–90]

Inhibit TGF-β1 and PDGF expressions, regulate MMPs/TIMPs balance, increase IL-12 production, suppress HSC activation, apply to CHC and CHB patients

Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae, Radix Ginseng, Fructus Jujubae, Radix Glycyrrhizae

Buzhong Yiqi Tang[91, 92]

Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients

Radix Astragali, Radix Glycyrrhizae, Radix Ginseng, Radix Angelicae Sinensis, Pericarpium citri reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Rhizoma Atractylodis macrocephalae

Renshen Yangrong Tang[92–94]

Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients

Radix Astragali, Radix Angelicae sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Pericarpium citri reticulatae, Rhizoma Atractylodis macrocephalae, Radix Ginseng, Radix Paeoniae alba, Radix Rehmanniae, Fructus Schisandrae chinensis, Poria, Cortex et Radix Polygalae

Fufang Jinsan E[95]

Inhibit TGF-β1 and Smad3, Up-regulate Smad7 in liver fibrotic rats

Radix Curcumae, Rhizoma Sparganii, Rhizoma Curcumae

Denshen Taoxiong Tang[96]

Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse

Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Chuanxiong

Ershen Zezhu Tang[96]

Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse

Radix Codonopsis, Radix Salviae miltiorrhizae, Rhizoma Atractylodis macrocephalae, Rhizoma Alismatis

Buqi Jianzhong Tang[97, 98]

Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites

Largehead Atractyloidis Rhizoma, Hoelen, Aurantii Nobilis Pericarpium, Radix Ginseng, Radix Scutellariae, Magnolia Bark, Alisma Rhizoma, Radix Ophiopogonis, Atractylodis Rhizoma

Fangji Tang[97, 98]

Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites

Sinomeni Claulis Et Rhizoma, Mori Contex, Hoelen

Preilla Herba, Saussurae Radis

Handan Ganle[99–102]

Anti-oxidatation, collagenolytic effect, regulate MMPs/TIMPs balance, apply to CHB patients

Radix Sophorae Flavescentis, Radix Salviae miltiorrhizae, Radix Paeoniae, Radix Astragali, Folium Ginkgo

Ganzhifu[103]

Anti-oxidation, reduce collagens, anti-liver fibrosis in liver fibrotic rats

Rhizoma Zingiberis, Ramulus Cinnmomi, Radix Aconiti Lateralis preparata, Radix Astragali, Radix Bupleuri, Fructus Aurantii, Rhizoma Atractylodis macrocephalae, Radix Glycyrrhizae

Fuzheng Huay[104–108]

Significantly decrease HA, LM, P-III-P and IV-C content, improve serum Alb, ALT, AST, GGT, LM, HA, Hyp and ration of BCAA/AAA in animals and CHB patients. Inhibit HSCs activation via FN/integrin signaling.

Radix Salvia miltiorrhizae, Cordyceps mycelia extract, Semen Persicae, Gynostemma Pentaphyllammak, Pollen Pini, Fructus schisandrae chinensis