From: Chinese medicines as a resource for liver fibrosis treatment
Composite formulae and major references | Pharmacological actions and clinical indications | Compositions of formulae |
---|---|---|
Induce HSCs apoptosis, inhibit HSCs activation, reduce collagen deposition and α-SMA and decrease the serum level of HA, apply to postoperative biliary atresia patients and icteric patients with cirrhosis | Herba Artemisiae Scopariae, Radix et Rhizoma Rhei, Fructus Gardeniae | |
Inhibit TGF-β1 and PDGF expressions, regulate MMPs/TIMPs balance, increase IL-12 production, suppress HSC activation, apply to CHC and CHB patients | Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae, Radix Ginseng, Fructus Jujubae, Radix Glycyrrhizae | |
Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients | Radix Astragali, Radix Glycyrrhizae, Radix Ginseng, Radix Angelicae Sinensis, Pericarpium citri reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Rhizoma Atractylodis macrocephalae | |
Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients | Radix Astragali, Radix Angelicae sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Pericarpium citri reticulatae, Rhizoma Atractylodis macrocephalae, Radix Ginseng, Radix Paeoniae alba, Radix Rehmanniae, Fructus Schisandrae chinensis, Poria, Cortex et Radix Polygalae | |
Fufang Jinsan E[95] | Inhibit TGF-β1 and Smad3, Up-regulate Smad7 in liver fibrotic rats | Radix Curcumae, Rhizoma Sparganii, Rhizoma Curcumae |
Denshen Taoxiong Tang[96] | Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse | Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Chuanxiong |
Ershen Zezhu Tang[96] | Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse | Radix Codonopsis, Radix Salviae miltiorrhizae, Rhizoma Atractylodis macrocephalae, Rhizoma Alismatis |
Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites | Largehead Atractyloidis Rhizoma, Hoelen, Aurantii Nobilis Pericarpium, Radix Ginseng, Radix Scutellariae, Magnolia Bark, Alisma Rhizoma, Radix Ophiopogonis, Atractylodis Rhizoma | |
Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites | Sinomeni Claulis Et Rhizoma, Mori Contex, Hoelen Preilla Herba, Saussurae Radis | |
Anti-oxidatation, collagenolytic effect, regulate MMPs/TIMPs balance, apply to CHB patients | Radix Sophorae Flavescentis, Radix Salviae miltiorrhizae, Radix Paeoniae, Radix Astragali, Folium Ginkgo | |
Ganzhifu[103] | Anti-oxidation, reduce collagens, anti-liver fibrosis in liver fibrotic rats | Rhizoma Zingiberis, Ramulus Cinnmomi, Radix Aconiti Lateralis preparata, Radix Astragali, Radix Bupleuri, Fructus Aurantii, Rhizoma Atractylodis macrocephalae, Radix Glycyrrhizae |
Significantly decrease HA, LM, P-III-P and IV-C content, improve serum Alb, ALT, AST, GGT, LM, HA, Hyp and ration of BCAA/AAA in animals and CHB patients. Inhibit HSCs activation via FN/integrin signaling. | Radix Salvia miltiorrhizae, Cordyceps mycelia extract, Semen Persicae, Gynostemma Pentaphyllammak, Pollen Pini, Fructus schisandrae chinensis |