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Table 2 Anti-fibrosis effect of composite formulae

From: Chinese medicines as a resource for liver fibrosis treatment

Composite formulae and major references Pharmacological actions and clinical indications Compositions of formulae
Yinchenhao Tang [6978] Induce HSCs apoptosis, inhibit HSCs activation, reduce collagen deposition and α-SMA and decrease the serum level of HA, apply to postoperative biliary atresia patients and icteric patients with cirrhosis Herba Artemisiae Scopariae, Radix et Rhizoma Rhei, Fructus Gardeniae
Xiao Chaihu Tang[7990] Inhibit TGF-β1 and PDGF expressions, regulate MMPs/TIMPs balance, increase IL-12 production, suppress HSC activation, apply to CHC and CHB patients Radix Bupleuri, Radix Scutellariae, Rhizoma Pinelliae, Radix Ginseng, Fructus Jujubae, Radix Glycyrrhizae
Buzhong Yiqi Tang[91, 92] Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients Radix Astragali, Radix Glycyrrhizae, Radix Ginseng, Radix Angelicae Sinensis, Pericarpium citri reticulatae, Rhizoma Cimicifugae, Radix Bupleuri, Rhizoma Atractylodis macrocephalae
Renshen Yangrong Tang[9294] Immunoregulation, inhibit TGF-β1 and IL-13 production, apply to CHC patients Radix Astragali, Radix Angelicae sinensis, Cortex Cinnamomi, Radix Glycyrrhizae, Pericarpium citri reticulatae, Rhizoma Atractylodis macrocephalae, Radix Ginseng, Radix Paeoniae alba, Radix Rehmanniae, Fructus Schisandrae chinensis, Poria, Cortex et Radix Polygalae
Fufang Jinsan E[95] Inhibit TGF-β1 and Smad3, Up-regulate Smad7 in liver fibrotic rats Radix Curcumae, Rhizoma Sparganii, Rhizoma Curcumae
Denshen Taoxiong Tang[96] Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse Radix Salviae Miltiorrhizae, Semen Persicae, Rhizoma Chuanxiong
Ershen Zezhu Tang[96] Anti-ascites, regulate urine sodium concentration in liver fibrotic mouse Radix Codonopsis, Radix Salviae miltiorrhizae, Rhizoma Atractylodis macrocephalae, Rhizoma Alismatis
Buqi Jianzhong Tang[97, 98] Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites Largehead Atractyloidis Rhizoma, Hoelen, Aurantii Nobilis Pericarpium, Radix Ginseng, Radix Scutellariae, Magnolia Bark, Alisma Rhizoma, Radix Ophiopogonis, Atractylodis Rhizoma
Fangji Tang[97, 98] Diuretic effect, increase excretion Na+, reduce GPT and GOT, apply to cirrhosis ascites Sinomeni Claulis Et Rhizoma, Mori Contex, Hoelen Preilla Herba, Saussurae Radis
Handan Ganle[99102] Anti-oxidatation, collagenolytic effect, regulate MMPs/TIMPs balance, apply to CHB patients Radix Sophorae Flavescentis, Radix Salviae miltiorrhizae, Radix Paeoniae, Radix Astragali, Folium Ginkgo
Ganzhifu[103] Anti-oxidation, reduce collagens, anti-liver fibrosis in liver fibrotic rats Rhizoma Zingiberis, Ramulus Cinnmomi, Radix Aconiti Lateralis preparata, Radix Astragali, Radix Bupleuri, Fructus Aurantii, Rhizoma Atractylodis macrocephalae, Radix Glycyrrhizae
Fuzheng Huay[104108] Significantly decrease HA, LM, P-III-P and IV-C content, improve serum Alb, ALT, AST, GGT, LM, HA, Hyp and ration of BCAA/AAA in animals and CHB patients. Inhibit HSCs activation via FN/integrin signaling. Radix Salvia miltiorrhizae, Cordyceps mycelia extract, Semen Persicae, Gynostemma Pentaphyllammak, Pollen Pini, Fructus schisandrae chinensis