Effects of Astragaloside IV on heart failure in rats

Chinese Medicine

Table 1 Effects of ASI on FS (%)

Group	Dose (mg/kg/day)	Normal	Before treatment	After treatment
Group	Dose (mg/kg/day)	Normal	Before treatment	1 week	2 weeks
Sham	-	73.0 ± 5.7	68.8 ± 6.5	70.9 ± 3.4	66.1 ± 8.0
Model	-	68.8 ± 10.1 (0.2193)	30.8 ± 5.0⁺⁺⁺	26.1 ± 6.6⁺⁺⁺	22.7 ± 7.6⁺⁺⁺
ASI	0.1	72.8 ± 3.6 (0.2417)	28.9 ± 4.6 (0.4213)	34.2 ± 7.5* (0.0163)	27.4 ± 7.8 (0.2620)
ASI	0.3	72.1 ± 9.6 (0.3329)	28.8 ± 6.9 (0.3973)	41.5 ± 11.3***	28.8 ± 8.9 (0.1474)
ASI	1.0	68.4 ± 6.7 (0.9061)	31.7 ± 2.5 (0.7024)	42.9 ± 7.7***	35.8 ± 13.2** (0.0028)
Quinapril	1.0	70.1 ± 7.5 (0.7016)	30.2 ± 4.7 (0.7989)	42.4 ± 4.7***	31.4 ± 8.8* (0.0411)

Note: Values are mean ± SD in each group (n = 10). ⁺⁺⁺P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001: statistical significances over the model group (comparison of group means after ANOVA). No statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments. Exact P values are available in brackets.

ISSN: 1749-8546