|  |  |  |  | After treatment | |
---|---|---|---|---|---|---|
Group | Dose (mg/kg/day) | Normal | Before treatment | 1 week | 2 weeks | |
 | Sham | - | 4.8 ± 1.0 | 5.2 ± 1.3 | 5.2 ± 0.7 | 5.2 ± 0.9 |
 | Model | - | 4.8 ± 1.2 (0.9549) | 7.0 ± 1.1++ (0.0046) | 7.5 ± 0.4+++ | 7.1 ± 0.7+++ |
LVIDd (mm) | ASI | 0.1 | 5.0 ± 0.8 (0.6785) | 6.9 ± 1.2 (0.9603) | 6.9 ± 1.0 (0.1601) | 6.5 ± 1.1 (0.1109) |
 | ASI | 0.3 | 4.5 ± 1.2 (0.5850) | 6.2 ± 1.9 (0.1946) | 6.7 ± 1.7 (0.0547) | 6.0 ± 0.9** (0.0057) |
 | ASI | 1.0 | 4.7 ± 1.5 (0.7629) | 6.4 ± 1.3 (0.3389) | 6.5 ± 0.8* (0.0193) | 6.0 ± 0.5**$ (0.0046) |
 | Quinapril | 1.0 | 5.1 ± 1.2 (0.6512) | 6.6 ± 1.1 (0.5964) | 6.7 ± 0.8 (0.0574) | 6.7 ± 0.9 (0.3837) |
 | Sham | - | 1.3 ± 0.4 | 1.6 ± 0.4 | 1.5 ± 0.3 | 1.8 ± 0.5 |
 | Model | - | 1.5 ± 0.5 (0.4268) | 4.8 ± 1+++ | 5.6 ± 0.8+++ | 5.5 ± 0.8+++ |
LVIDs (mm) | ASI | 0.1 | 1.4 ± 0.3 (0.8811) | 4.9 ± 0.9 (0.8356) | 4.5 ± 0.9* (0.0112) | 4.7 ± 0.9* (0.0447) |
 | ASI | 0.3 | 1.2 ± 0.4 (0.1827) | 4.5 ± 1.6 (0.3955) | 4.0 ± 1.6*** | 4.3 ± 1.0** (0.0027) |
 | ASI | 1.0 | 1.4 ± 0.4 (0.6903) | 4.4 ± 0.8 (0.3353) | 3.7 ± 0.7*** | 3.8 ± 1.0***$ |
 | Quinapril | 1.0 | 1.6 ± 0.7 (0.5180) | 4.6 ± 0.7 (0.6125) | 3.9 ± 0.6*** | 4.8 ± 0.8 (0.0595) |