Skip to main content

Table 3 Effects of ASI on LV dimensions

From: Effects of Astragaloside IV on heart failure in rats

     

After treatment

Group

Dose (mg/kg/day)

Normal

Before treatment

1 week

2 weeks

 

Sham

-

4.8 ± 1.0

5.2 ± 1.3

5.2 ± 0.7

5.2 ± 0.9

 

Model

-

4.8 ± 1.2 (0.9549)

7.0 ± 1.1++ (0.0046)

7.5 ± 0.4+++

7.1 ± 0.7+++

LVIDd (mm)

ASI

0.1

5.0 ± 0.8 (0.6785)

6.9 ± 1.2 (0.9603)

6.9 ± 1.0 (0.1601)

6.5 ± 1.1 (0.1109)

 

ASI

0.3

4.5 ± 1.2 (0.5850)

6.2 ± 1.9 (0.1946)

6.7 ± 1.7 (0.0547)

6.0 ± 0.9** (0.0057)

 

ASI

1.0

4.7 ± 1.5 (0.7629)

6.4 ± 1.3 (0.3389)

6.5 ± 0.8* (0.0193)

6.0 ± 0.5**$ (0.0046)

 

Quinapril

1.0

5.1 ± 1.2 (0.6512)

6.6 ± 1.1 (0.5964)

6.7 ± 0.8 (0.0574)

6.7 ± 0.9 (0.3837)

 

Sham

-

1.3 ± 0.4

1.6 ± 0.4

1.5 ± 0.3

1.8 ± 0.5

 

Model

-

1.5 ± 0.5 (0.4268)

4.8 ± 1+++

5.6 ± 0.8+++

5.5 ± 0.8+++

LVIDs (mm)

ASI

0.1

1.4 ± 0.3 (0.8811)

4.9 ± 0.9 (0.8356)

4.5 ± 0.9* (0.0112)

4.7 ± 0.9* (0.0447)

 

ASI

0.3

1.2 ± 0.4 (0.1827)

4.5 ± 1.6 (0.3955)

4.0 ± 1.6***

4.3 ± 1.0** (0.0027)

 

ASI

1.0

1.4 ± 0.4 (0.6903)

4.4 ± 0.8 (0.3353)

3.7 ± 0.7***

3.8 ± 1.0***$

 

Quinapril

1.0

1.6 ± 0.7 (0.5180)

4.6 ± 0.7 (0.6125)

3.9 ± 0.6***

4.8 ± 0.8 (0.0595)

  1. Note: Values are mean ± SD in each group (n = 10). ++P < 0.01, +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001: statistical significance over the model group (comparison of group means after ANOVA). $P < 0.05: statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.