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Table 4 Effects of ASI on LVSP, LVEDP and wall stress

From: Effects of Astragaloside IV on heart failure in rats

Group Dose (mg/kg/day) LVSP (mmHg) LVEDP (mmHg) Wall stress (g/cm2)
Sham - 111.8 ± 12.1 -0.7 ± 5.8 47.7 ± 17.6
Model - 88.5 ± 14.0+++ 13.9 ± 5.4+++ 125.9 ± 28.0+++
ASI 0.1 101.4 ± 18.5* (0.0367) 10.6 ± 3.6 (0.1629) 120.4 ± 31.9 (0.6563)
ASI 0.3 101.6 ± 9.0* (0.0340) 9.8 ± 5.3 (0.0848) 108.3 ± 24.5 (0.1613)
ASI 1.0 100.2 ± 8.4$$ (0.0571) 6.2 ± 4.2** (0.0018) 97.9 ± 29.8* (0.0283)
Quinapril 1.0 84.0 ± 15.5 (0.4566) 3.5 ± 6.3*** 95.1 ± 31.7* (0.0167)
  1. Note: Values are mean ± SD in each group (n = 10). +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01, ***P < 0.001: statistical significance over the model group (comparison of group means after ANOVA). $$P < 0.01: statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.