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Table 5 Effects of ASI on myocardial hypertrophy

From: Effects of Astragaloside IV on heart failure in rats

Group

Dose (mg/kg/day)

LA wt/TL (mg/mm)

LV wt/TL (mg/mm)

RA wt/TL (mg/mm)

RV wt/TL (mg/mm)

Tibial length (mm)

Body weight (g)

Sham

-

1.3 ± 0.6

20.3 ± 3.1

1.8 ± 0.6

5.5 ± 1.5

37.25 ± 1.23

290.2 ± 23.2

Model

-

2.8 ± 0.7+++

24.9 ± 2.1+++

2.6 ± 0.5+++

8.1 ± 1.5+++

38.20 ± 1.70

280.1 ± 24.3

  

-

 

-

 

(0.1879)

(0.3439)

ASI

0.1

2.4 ± 0.4

22.7 ± 2.8

2.5 ± 0.4

7.1 ± 1.0

38.96 ± 1.28

271.2 ± 18.0

  

(0.1855)

(0.0862)

(0.6751)

(0.1031)

(0.2723)

(0.4038)

ASI

0.3

2.5 ± 0.7

22.6 ± 4.0

2.5 ± 0.5

7.1 ± 1.2

37.23 ± 1.36

287.9 ± 31.6

  

(0.2280)

(0.0796)

(0.7632)

(0.099)

(0.1811)

(0.4639)

ASI

1.0

2.1 ± 0.6*

21.0 ± 2.6**

2.0 ± 0.7*

6.1 ± 1.3**

37.89 ± 1.28

294.5 ± 15.7

  

(0.015)

(0.0031)

(0.0186)

(0.0017)

(0.6827)

(0.1794)

Quinapril

1.0

2.0 ± 0.8**

22.0 ± 1.8*

2.0 ± 0.6*

7.2 ± 1.8

38.13 ± 2.27

280.1 ± 25.6

  

(0.0076)

(0.0255)

(0.0223)

(0.1485)

(0.9434)

(1.0)

  1. Note: Values are mean ± SD in each group (n = 10). +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01: statistical significance over the model group (comparison of group means after ANOVA). No statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.