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Table 5 Effects of ASI on myocardial hypertrophy

From: Effects of Astragaloside IV on heart failure in rats

Group Dose (mg/kg/day) LA wt/TL (mg/mm) LV wt/TL (mg/mm) RA wt/TL (mg/mm) RV wt/TL (mg/mm) Tibial length (mm) Body weight (g)
Sham - 1.3 ± 0.6 20.3 ± 3.1 1.8 ± 0.6 5.5 ± 1.5 37.25 ± 1.23 290.2 ± 23.2
Model - 2.8 ± 0.7+++ 24.9 ± 2.1+++ 2.6 ± 0.5+++ 8.1 ± 1.5+++ 38.20 ± 1.70 280.1 ± 24.3
   -   -   (0.1879) (0.3439)
ASI 0.1 2.4 ± 0.4 22.7 ± 2.8 2.5 ± 0.4 7.1 ± 1.0 38.96 ± 1.28 271.2 ± 18.0
   (0.1855) (0.0862) (0.6751) (0.1031) (0.2723) (0.4038)
ASI 0.3 2.5 ± 0.7 22.6 ± 4.0 2.5 ± 0.5 7.1 ± 1.2 37.23 ± 1.36 287.9 ± 31.6
   (0.2280) (0.0796) (0.7632) (0.099) (0.1811) (0.4639)
ASI 1.0 2.1 ± 0.6* 21.0 ± 2.6** 2.0 ± 0.7* 6.1 ± 1.3** 37.89 ± 1.28 294.5 ± 15.7
   (0.015) (0.0031) (0.0186) (0.0017) (0.6827) (0.1794)
Quinapril 1.0 2.0 ± 0.8** 22.0 ± 1.8* 2.0 ± 0.6* 7.2 ± 1.8 38.13 ± 2.27 280.1 ± 25.6
   (0.0076) (0.0255) (0.0223) (0.1485) (0.9434) (1.0)
  1. Note: Values are mean ± SD in each group (n = 10). +++P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, **P < 0.01: statistical significance over the model group (comparison of group means after ANOVA). No statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA). Exact P values are available in brackets.