Effects of Astragaloside IV on heart failure in rats

Chinese Medicine

Table 6 Effects of ASI on myocardial apoptosis and Bax

Group	Dose (mg/kg/day)	Apoptotic cell	Bax protein
Sham	-	3.0 ± 2.2	1.6 ± 1.3
Model	-	54.0 ± 10.2⁺⁺⁺	30.2 ± 8.8⁺⁺⁺
ASI	0.1	37.8 ± 8.6***	24.3 ± 7.1*
ASI	0.3	17.0 ± 8.4***	8.4 ± 5.3***
ASI	1.0	8.0 ± 5.6***	7.3 ± 3.4***
Quinapril	1.0	10.4 ± 6.4***	12.0 ± 5.5***

Note: Values are mean ± SD in each group (n = 10). ⁺⁺⁺P < 0.001: statistical significance over the sham group (comparison of group means after ANOVA). *P < 0.05, ***P < 0.001: statistical significance over the model group (comparison of group means after ANOVA). No statistical significance between ASI (1.0 mg/kg/day) and Quinapril treatments (comparison of group means after ANOVA).

ISSN: 1749-8546