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Table 2 Intra- and interday variability for the assay of the three Panax notoginseng saponins in beagle dog plasma (n = 6)

From: Simultaneous determination of three major bioactive saponins of Panax notoginseng using liquid chromatography-tandem mass spectrometry and a pharmacokinetic study

Spiked conc.

(ng/mL)

Intraday

Interday

Measured conc. (ng/mL)

RSD (%) a

Accuracy (%) b

Measured conc. (ng/mL)

RSD (%)

Accuracy (%)

Notoginsenoside R1

      

2.8

2.8

1.27

100.0

2.68

1.49

95.71

14

13.9

0.76

99.29

12.89

9.62

92.1

140

148

8.22

105.7

131.67

10.11

105.7

Ginsenoside Rg1

      

3.8

3.6

5.13

94.7

3.96

11.96

104.2

19

17.6

3.65

92.6

18.3

8.95

96.3

190

197.3

6.59

103.8

193.7

7.66

101.7

Ginsenoside Rb1

      

18

18.1

3.07

100.6

17.6

5.36

96.11

180

165.3

2.73

91.83

179.7

5.05

99.50

900

912.67

3.90

101.3

871.3

2.38

96.87

  1. Note: aRelative standard deviation; bAccuracy (%) = [1--(nominal concentration -- mean of measured concentration)/nominal concentration] × 100
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Chinese Medicine

ISSN: 1749-8546

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