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Table 1 Bioactivities of compounds isolated from A. paniculata

From: Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Names Bioactivities References
Andrographolide Bioactivities  
14-deoxyandrographolide activation of NOS and guanylate cyclase
vasorelaxation in vitro and in vivo
[102, 103, 106]
neoandrographolide NO, PGE2, iNOS and COX-2 in activated macrophages
CCl4, tBHP-induced hepatotoxicity (i.p 100 mg/kg, 3d)
[34, 35, 91]
14-deoxy-11,12-didehydroandrographolide muscle relexation.
NO release from endothelial cells
[107, 105]
14-deoxy-14,15-didehydroandrographolide cytotoxic activity and cell cycle arrest of tumor cells
NF-κB-dependent trans-activation
[42, 17]
andrograpanin protein kinase or p38 MAPKs pathways
chemokine SDF-1α induced chemotaxis in Jurkat and THP-1 cells
[37, 87]
isoandrographolide cell-differentiation-inducing activity
proliferation of HL-60 cells
[10, 44]
14-acetylandrographolide growth of leukeamia, ovarian, renal cancer cells [47]
19-O-acetylanhydroandrographolide NF-κB-dependent trans-activation [17]