Table 1 Bioactivities of compounds isolated from A. paniculata

Andrographolide

Bioactivities

14-deoxyandrographolide

activation of NOS and guanylate cyclase

vasorelaxation in vitro and in vivo

[102, 103, 106]

neoandrographolide

NO, PGE₂, iNOS and COX-2 in activated macrophages

CCl₄, tBHP-induced hepatotoxicity (i.p 100 mg/kg, 3d)

[34, 35, 91]

14-deoxy-11,12-didehydroandrographolide

muscle relexation.

NO release from endothelial cells

[107, 105]

14-deoxy-14,15-didehydroandrographolide

cytotoxic activity and cell cycle arrest of tumor cells

NF-κB-dependent trans-activation

[42, 17]

andrograpanin

protein kinase or p38 MAPKs pathways

chemokine SDF-1α induced chemotaxis in Jurkat and THP-1 cells

[37, 87]

isoandrographolide

cell-differentiation-inducing activity

proliferation of HL-60 cells

[10, 44]

14-acetylandrographolide

growth of leukeamia, ovarian, renal cancer cells

[47]

19-O-acetylanhydroandrographolide

NF-κB-dependent trans-activation

[17]