Table 1 Bioactivities of compounds isolated from A. paniculata
From: Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)
| Names | Bioactivities | References |
|---|---|---|
| Andrographolide | Bioactivities | |
| 14-deoxyandrographolide |
activation of NOS and guanylate cyclase vasorelaxation in vitro and in vivo | [102, 103, 106] |
| neoandrographolide |
NO, PGE2, iNOS and COX-2 in activated macrophages CCl4, tBHP-induced hepatotoxicity (i.p 100 mg/kg, 3d) | [34, 35, 91] |
| 14-deoxy-11,12-didehydroandrographolide |
muscle relexation. NO release from endothelial cells | [107, 105] |
| 14-deoxy-14,15-didehydroandrographolide |
cytotoxic activity and cell cycle arrest of tumor cells NF-κB-dependent trans-activation | [42, 17] |
| andrograpanin |
protein kinase or p38 MAPKs pathways chemokine SDF-1α induced chemotaxis in Jurkat and THP-1 cells | [37, 87] |
| isoandrographolide |
cell-differentiation-inducing activity proliferation of HL-60 cells | [10, 44] |
| 14-acetylandrographolide | growth of leukeamia, ovarian, renal cancer cells | [47] |
| 19-O-acetylanhydroandrographolide | NF-κB-dependent trans-activation | [17] |