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Table 5 Bioactivities of synthetic analogues of andrographolide

From: Isolation and identification of bioactive compounds in Andrographis paniculata (Chuanxinlian)

Name Bioactivities References
Derivatives of 12-hydroxy-14-dehydroandrographolide   TNF-α and IL-6 secretion in mouse macrophages [13]
3,19-O-diacetylanhydroandrographolide   NF-κB-dependent trans-activation in the RAW264.7 cells [17]
DRF3188 block MCF-7 cell cycle at the G0/G1 phase
  cell cycle inhibitor, p27
  the levels of CDK4
14-Alphal-lipoyl andrographolide   against H9N2, H5N1 and H1N1 viruses to reduced the death rate, prolonged life and inhibited lung consolidation and viral titers [83]
14-Glycinyl andrographolide hydrochloride   reduced virulence factor production [84]
SRJ23   G1 arrest and apoptosis in MCF-7 and HCT-116 [62]
SRJ09   G1 arrest and apoptosis in MCF-7 and HCT-116 [62]
3,19-isopropylideneandrographolide  cyotoxicity against MCF-7 and HCT-116 [47]
14-acetyl-3,19-isopropylidene andrographolide  cyotoxicity against MCF-7 and HCT-116 [47]