Table 5 Bioactivities of synthetic analogues of andrographolide

Derivatives of 12-hydroxy-14-dehydroandrographolide

  TNF-α and IL-6 secretion in mouse macrophages

[13]

3,19-O-diacetylanhydroandrographolide

  NF-κB-dependent trans-activation in the RAW264.7 cells

[17]

DRF3188

block MCF-7 cell cycle at the G0/G1 phase

  cell cycle inhibitor, p27

  the levels of CDK4

[46]

14-Alphal-lipoyl andrographolide

  against H9N2, H5N1 and H1N1 viruses to reduced the death rate, prolonged life and inhibited lung consolidation and viral titers

[83]

14-Glycinyl andrographolide hydrochloride

  reduced virulence factor production

[84]

SRJ23

  G1 arrest and apoptosis in MCF-7 and HCT-116

[62]

SRJ09

  G1 arrest and apoptosis in MCF-7 and HCT-116

[62]

3,19-isopropylideneandrographolide

 cyotoxicity against MCF-7 and HCT-116

[47]

14-acetyl-3,19-isopropylidene andrographolide

 cyotoxicity against MCF-7 and HCT-116

[47]