Antiviral biflavonoids from Radix Wikstroemiae (Liaogewanggen)

Chinese Medicine

Table 1 In vitro anti-RSV activity of compounds I-IV (n = 3)

Compound	CC₅₀(μM) ^a	IC₅₀(μM) ^b	SI
I	29.9 (3.2)	-	-
II	106.1 (5.9)	9.6 (0.7)	11.0
III	145.3 (3.1)	6.6 (1.1)	21.9
IV	161.5 (5.7)	10.2 (0.8)	15.8
Ribavirin	256.1 (3.2)	11.9 (0.2)	21.6

^a CC₅₀ is the concentration of sample with half maximal inhibition on the growth and survival of HEp-2 cells; data are expressed as mean (SD).
^b IC₅₀ is the concentration that reduced 50% of CPE in respect to virus control; data are expressed as mean (SD).
-: The sample did not show anti-RSV effect at its NMCC.

ISSN: 1749-8546