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Table 1 Microscopic observation on protective and preventive effects of berberine against CCl4-induced acute liver damage in rats (n = 8).

From: Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats

Group Fatty degeneration
Mean (SD)
Vacoulisation
Mean (SD)
Nuclei
Mean (SD)
Hepatocyte necrosis
Mean (SD)
Inflammatory cells infiltration
Mean (SD)
Central vein and portal triad
Mean (SD)
Combined score
Mean (SD)
Normal 0.6 (0.3) 0.3 (0.2) 1.3 (0.3) 0.5 (0.1) 0.7 (0.3) 2.2 (0.6) 1.2 (0.3)
CCl4 5.5 (1.2)** 4.8 (0.4) ** 0.3 (0.2) ** 5.7 (1.9) ** 5.5 (1.5) ** 0.4 (0.2) ** 4.7 (0.9)##
Post-treated with berberine        
80 mg/kg 3.2 (1.6) ## 2.5 (0.7) ## 1.7 (0.3) ## 2.2 (0.4) ## 2.7 (1.1) ## 1.2 (0.5) ## 3.0 (1.3) ##
120 mg/kg 1.7 (1.3)## 1.8 (0.2) ## 1.7 (0.5) ## 1.6 (0.8) ## 1.8 (0.2) ## 2.1 (0.6) ## 1.8 (0.9) ##
160 mg/kg 1.4 (0.9) ## 1.2 (0.4) ## 1.4 (0.4) ## 1.2 (0.5) ## 1.1 (0.4) ## 1.5 (0.8) ## 1.1 (0.8) ##
Pre-treated with berberine        
120 mg/kg 2.1 (1.3) ## 2.3 (1.6) ## 1.0 (0.7) ## 2.0 (1.4) ## 1.5 (0.6) ## 2.5 (0.4) ## 2.8 (1.4) ##
  1. **P < 0.001 when compared with normal group; ##P < 0.001 when compared with CCl4 group. The P values higher than 0.001 were denoted after the means.