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Table 1 Relative binding affinities of major constituents of ERr and estradiol

From: Treatment of menopausal symptoms by an extract from the roots of rhapontic rhubarb: the role of estrogen receptors

Substance IC50 ERα IC50 ERβ Fold preference for ERβ
Estradiol 8 × 10-9 6.7 × 10-9 0.84
Trans-rhapontigenin 1.2 × 10-5 5.6 × 10-6 2.14
Desoxyrhapontigenin 2.6 × 10-5 2.8 × 10-5 1.1
  1. Note:
  2. Relative binding affinities of trans-rhapontigenin and desoxyrhapontigenin were assessed by a fluorescence polarization assay. IC50 values of compounds in comparison to estradiol and relative preference for the receptor subtypes are shown.