Table 1 Possible pharmacological actions of Radix Angelica Sinensis on cerebral infarction
From: Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction
Pharmacological actions | Related components | Possible mechanisms |
|---|---|---|
Anti-arthrosclerosis effects | Danggui and sodium ferulate | reverse the reduction of TGB-β/reverse the increase of bFGF [24] |
Danggui | reduce the increase of serum malonyldialdehyde (MDA) levels [25] | |
sodium ferulated | decrease the levels of triglyceride [11] | |
Vasodilatation and improving microcirculation effects | Danggui | increase the formation of NO and mediate the inhibition of calcium influx [10] |
sodium ferulate | increase the generation of NO [11] | |
Ligustilide | inhibit prostaglandin F-2α, oxytocin, acetylcholine chloride, and potassium depolarization-induced muscle contraction [12] | |
Ligustilide | increase the number of opened capillary and the speed of blood flow [13] | |
Ferulic acid | enhance acetylcholine-induced vasodilatation and reduce the production of thromboxane B2 [14] | |
Anti-platelet aggregation effects | Danggui and sodium ferulate | inhibit ADP-induced and collagen-induced platelet aggregation [27] |
Z-Ligustilide | inhibit ADP-induced platelet aggregation [28] | |
Anti-inflammatory effects | Ferulic acid | inhibit ICAM-1 and NF-κB expression [33] |
Ferulic acid | enhance gamma-aminobutyric acid type B1 (GABAB1) receptor expression [34] | |
Danggui | reduce TNF-α and TGF-ß1 mRNA expression [35] | |
Danggui polysaccharides | reduce TNF-α levels [36] | |
Anti-oxidative effects | Ferulic acid | reduce the generation of NADPH-dependent production of superoxide anion [14] |
Ferulic acid | enhances the expression of GABAB1 receptor expression [34] | |
Z-ligustilide | reduce MDA levels and increase GSH-PX and SOD activities [42] |