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Table 1 Possible pharmacological actions of Radix Angelica Sinensis on cerebral infarction

From: Pharmacological effects of Radix Angelica Sinensis (Danggui) on cerebral infarction

Pharmacological actions Related components Possible mechanisms
Anti-arthrosclerosis effects Danggui and sodium ferulate reverse the reduction of TGB-β/reverse the increase of bFGF [24]
Danggui reduce the increase of serum malonyldialdehyde (MDA) levels [25]
sodium ferulated decrease the levels of triglyceride [11]
Vasodilatation and improving microcirculation effects Danggui increase the formation of NO and mediate the inhibition of calcium influx [10]
sodium ferulate increase the generation of NO [11]
Ligustilide inhibit prostaglandin F-2α, oxytocin, acetylcholine chloride, and potassium depolarization-induced muscle contraction [12]
Ligustilide increase the number of opened capillary and the speed of blood flow [13]
Ferulic acid enhance acetylcholine-induced vasodilatation and reduce the production of thromboxane B2 [14]
Anti-platelet aggregation effects Danggui and sodium ferulate inhibit ADP-induced and collagen-induced platelet aggregation [27]
Z-Ligustilide inhibit ADP-induced platelet aggregation [28]
Anti-inflammatory effects Ferulic acid inhibit ICAM-1 and NF-κB expression [33]
Ferulic acid enhance gamma-aminobutyric acid type B1 (GABAB1) receptor expression [34]
Danggui reduce TNF-α and TGF-ß1 mRNA expression [35]
Danggui polysaccharides reduce TNF-α levels [36]
Anti-oxidative effects Ferulic acid reduce the generation of NADPH-dependent production of superoxide anion [14]
Ferulic acid enhances the expression of GABAB1 receptor expression [34]
Z-ligustilide reduce MDA levels and increase GSH-PX and SOD activities [42]