Figure 9

Effects of CTS on VEGF/VEGFR2 and PDGF-A/PDGFRα expression in the cerebral cortex of SAMP8 with and without ischemic insult. After completing the behavioral studies, we decapitated the animals and extracted the total protein from the cerebral cortices as described in the text. (A) Typical photos indicating the expression levels of VEGF, VEGFR2, PDGF, and PDGFRα in the cerebral cortex of vehicle-treated SAMR1 control (lane 1), vehicle-treated sham-SAMP8 (lane 2), CTS (750 mg/kg/day)-treated sham-SAMP8 (lane 3), vehicle-treated T2VO-SAMP8 (lane 4), and CTS-treated T2VO-SAMP8 group (lane 5). (B) Quantitative comparisons of each factor among different animal groups were conducted as described in the text. The data are expressed as the percentage of the value obtained from naïve control SAMR1 mice. Each data column represents the mean ± SD obtained from five brain samples. ^#P < 0.05, ^##P < 0.01 and ^###P < 0.001 vs. vehicle-treated SAMR1 group (t-test). ***P < 0.001 vs. respective vehicle-treated sham- or T2VO-SAMP8group (two-way ANOVA).