Cytotoxic and apoptotic effects of six herbal plants against the human hepatocarcinoma (HepG2) cell line

Chinese Medicine

Table 2 Percent yields and cytotoxic activities.

Sample	Part used	Percent yield	IC₅₀ (μg/ml) ± standard deviation (SD)		SI^c
			HepG2	Vero
Melphalan^a			37.7 ± 9.8	59.9 ± 3.2	1.6
Glochidion daltonii	Woody stem and twig	4.3	109.1 ± 8.8	38.7 ± 10.0	0.7
Cladogynos orientalis	Leaves	7.4	402.0 ± 4.3	205.4 ± 5.6	0.5
Catimbium speciosum	Rhizomes	2.6	55.7 ± 8.1	19.7 ± 2.5	0.4
Acorus tatarinowii	Underground stem (rhizomes),	10.5	364.8 ± 6.6	182.5 ± 2.1	0.5
Amommum villosum	Pseudostem and leaves	7.21	119.2 ± 8.6	Inactive^b	> 4.2
Pinus kesiya	Woody twig	2.2	52.0 ± 5.8	Inactive^b	9.6

Percent yields of the crude extracts from six indigenous plants and their cytotoxic activities after 24-hour treatment in human hepatocarcinoma (HepG2) and normal African green monkey kidney epithelial (Vero) cell lines.
Data are expressed as the means of triplication.
^a Standard anticancer drug and positive control.
^b IC₅₀ > 500 μg/ml is considered to be inactive.
^c SI refers to Selectivity Index, SI value > 3 indicating high selectivity [9].

ISSN: 1749-8546