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Table 3 Inhibition of proliferation of SNU449, SNU182 and HepG2 human liver cancer cells by raw and steamed P. notoginsen g extracts

From: Anti-proliferative effects of raw and steamed extracts of Panax notoginseng and its ginsenoside constituents on human liver cancer cells

P. notoginseng IC50*(mg/ml)
SNU449 SNU182 HepG2
Raw - - -
Steamed 2 hours 0.80 0.78 0.89
Steamed 6 hours 0.30 0.27 0.27
Steamed 9 hours 0.24 0.16 0.21
Steamed 15 hours 0.21 0.16 0.17
Steamed 24 hours 0.14 0.14 0.13
  1. * IC50 = 50% inhibition concentration
  2. Note: The cells were exposed to the extracts at 0.1, 0.25, 0.50, 0.75 and 1 mg/ml for 48 hours (SNU449 and SNU182) and 72 hours (HepG2). The IC50 values were determined using Calcusyn software for dose effect analysis. The IC50 value for raw P. notoginseng cannot be determined. For the steamed P. notoginseng, the IC50 decreased with the increase in the steaming duration.