Figure 4
Effects PKCε and mK ATP inhibitors on myocardial protection afforded by DG post-treatment. Animals were sacrificed at four hours after ISO challenge. PKCε translocation inhibitor and mKATP blocker (5-hydroxydecanoate, 5-HD) were intraperitoneally administered at a dose of 400 μg/kg one hour prior to the administration of the DG extract. Plasma enzyme activities and myocardial mitochondrial antioxidant parameters were measured as described in Figures 1 and 2. The non-striped bar represents the non-ISO-challenged group and the striped bar represents the ISO-challenged group. Values are means ± SD (n = 6). * Significantly different from the non-ISO-challenged CON; # significantly different from the ISO-challenged CON with inhibitors; † significantly different from the respective ISO-challenged CON