Expression of SYP in the hippocampal CA1 region in 7-month-old mice. The effects of GEPT on the expression of SYP in the hippocampal CA1 region in 7-month-old experimental mice were assessed by IHC staining. Average optical densities of the SYP positive neuronal area (anti-body for SYP, 1:400) are expressed as mean ± SD (n = 5). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone, P < 0.01 vs. APP mice; ▴▴P < 0.01 vs. control mice, ANOVA.