A combination extract of ginseng, epimedium, polygala, and tuber curcumae increases synaptophysin expression in APPV717I transgenic mice

Table 2 Escape latencies of 11-month-old mice

Group	Day 3	Day 4	Day 5
Control	39.17 ± 12.68	36.75 ± 14.72	33.08 ± 14.49
APP	51.33 ± 7.80^▲	49.83 ± 7.78^▲	47.17 ± 10.19^▲
APP + D	42.25 ± 14.23	40.00 ± 12.69	34.83 ± 13.60^●
APP + Gl	43.27 ± 10.32	37.64 ± 13.52^●	37.55 ± 13.92
APP + Gm	41.60 ± 10.51	43.60 ± 11.61	35.50 ± 13.91^●
APP + Gh	40.00 ± 12.34^●	38.83 ± 14.45^●	34.42 ± 12.38^●

The effects of GEPT on the escape latency in 7-month-old mice (n = 12) were assessed in orientation navigation tests using the Morris Water Maze (MWM). Data are expressed as mean ± standard deviation (SD). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone; ^▴P < 0.05 vs. control mice, one-way ANOVA.

ISSN: 1749-8546