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Table 3 Expression of SYP in the hippocampal CA1 region in 7- and 11-month-old mice

From: A combination extract of ginseng, epimedium, polygala, and tuber curcumae increases synaptophysin expression in APPV717I transgenic mice

Group Average optical density
7-month-old mice 11-month-old mice
Control 0.020 ± 0.002 0.026 ± 0.009
APP 0.013 ± 0.003▲▲ 0.015 ± 0.004
APP + D 0.017 ± 0.003 0.024 ± 0.008
APP + Gl 0.016 ± 0.003 0.027 ± 0.006
APP + Gm 0.017 ± 0.005 0.028 ± 0.007
APP + Gh 0.019 ± 0.005 0.031 ± 0.011
  1. The effects of GEPT extract on the expression of SYP in the hippocampal CA1 region in 7- and 11-month-old mice (n = 5 per group) were assessed by IHC staining. Average optical densities of the SYP positive neuronal area (anti-body for SYP, 1:400) are expressed as mean ± standard deviation (SD). Control: C57BL/6 J mice; APP: APPV717I mice; APP + D: APP mice treated with donepezil; APP + Gl: APP mice treated with GEPT (low dose); APP + Gm: APP mice treated with GEPT (medium dose); APP + Gh: APP mice treated with GEPT (high dose). P < 0.05 vs. APP mice alone, P < 0.01 vs. APP mice; P < 0.01 vs. control mice, one-way ANOVA.