Figure 2

Histopathologic sections of the liver in the BCG + LPS-induced model. (Group I) Liver sections of normal healthy mice show normal arrangements of cells in the liver lobules. (Group II) Hepatocyte necrosis and evident vacuolation of hepatocytes are observed in liver sections of BCG + LPS-treated mice. (Group III and Group IV) Liver sections of mice pretreated with bifendate at 0.40 g/kg body weight (Group III) or SRF at 0.05 g/kg body weight (Group IV) show mild vacuolation of hepatocytes. (Group V and Group VI) Mice pretreated with SRF at 0.10 mg/kg body weight (Group V) or 0.20 mg/kg body weight (Group VI) show marked improvement in the histology compared with the CCl₄-treated control group. HE staining; 100× magnification.