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Table 3 Major biofunctions of the identified proteins

From: Protective effect of Phellinus linteus polysaccharide extracts against thioacetamide-induced liver fibrosis in rats: a proteomics analysis

Protein name Subcellular location Major functions
Anti-oxidant effects   
hemopexin Extracellular region The highest binding affinity for heme, iron metabolism
preprohaptoglobin Extracellular region The highest binding affinity for hemoglobin
glutathione S-transferase alpha-4 (GSTA4) Cytoplasm GSH-related detoxification
betaine-homocysteine S-methyltransferase 1 (BHMT1) Cytoplasm cysteine metabolism and GSH synthesis regulation
Bckdha protein Mitochondrion matrix Branched-chain amino acids catabolism
Liver amelioration   
dihydrofolate reductase (DHFR) Cytoplasm Synthesis of nucleic acid precursors
quinoid dihydropteridine reductase (QDPR) Cytoplasm. Synaptosome Tetrahydrobiopterin recycle, amino acid metabolism
glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Cytoplasm. Nucleus. Glucose metabolism, initiation of apoptosis
ribonuclease UK114 Mitochondrion. Cytoplasm. Nucleus. Peroxisome Translational inhibition
galectin-5 Cytoplasm Cell surface of rat reticulocytes and erythrocytes Erythrocyte differentiation and reticulocyte maturation