Depressive-like behaviour. Studies were conducted in C57BL/6 J mice (N = 8). After 4 weeks of treatment with fluoxetine, XYS, and XYS/RTSES, the total duration of immobility (in seconds) in the mice was measured on the FST (A) and TST (B). Each value is expressed as the mean ± SD of 8 mice. *P < 0.05, **P < 0.01, ***P < 0.001, significant difference compared with control C57BL/6 J mice. #P < 0.05, ##P < 0.01, ###P < 0.001, significant difference compared with XYS alone.