Insulin and glucose dynamics. C57BL/6 J mice (N = 8) were evaluated and compared for insulin secretion. After 4 weeks of treatment with fluoxetine, XYS, and XYS/RTSES, the OGTT was performed for the regulation of plasma glucose (A) and the ITT was performed for the plasma glucose response (B) after fasting for 16 h. Each value is expressed as the mean ± SD of 8 mice. *P < 0.05, **P < 0.01, ***P < 0.001, significant difference compared with control C57BL/6 J mice. #P < 0.05, ##P < 0.01, ###P < 0.001, significant difference compared with XYS alone.