Effects of KOB03 on the infiltration of eosinophils into the nasal tissues of OVA sensitization/challenge-induced AR guinea pigs. (A) The nasal tissues were stained with Giemsa staining (magnification × 100). The arrows represent Giemsa-positive eosinophils infiltrating the nasal mucosa of guinea pigs. (B) The number of eosinophils in the nasal mucosa was counted by observing the sections under a microscope. **P < 0.01 vs. normal (a) or OVA-control (b). a, normal; b, OVA control; c, OVA + KOB03 (200 mg/kg)-administrated group; d, OVA + KOB03 (500 mg/kg)-administrated group; and e, OVA + ketotifen (10 mg/kg)-administrated group.