Study ID | Sample size | Intervention Group | Control Group | Duration Primary Outcomes | Secondary Outcomes | |
---|---|---|---|---|---|---|
Chen 2005 [24] | 49 | 'Fufang Biejia Ruangan Tablets' + IFN-γ (n = 28) | IFN-γ (n = 21) | 6 months | HA, LN, PC-III, IV-C & Knodell score | ALT & AST |
Chen 2006 [33] | 116 | Kang Xian Decoction + IFN-α (n = 58) | IFN-α (n = 58) | 6 months | HA, LN & PC-III | ALT & Improvement of related clinical symptoms |
Chen 2006_2 [20] | 138 | 'Qianggan Capsule' + conventional care (n = 68) | Placebo + conventional care (n = 70) | 6 months | HA, LN, PC-III & IV-C | ALT, Improvement of related clinical symptoms |
Chen 2007 [22] | 164 | Group I: Bie Jia Jian Pills + conventional care (n = 54) | IFN + conventional care (n = 52) | 9 months | HA, LN & PC-III | Â |
 |  | Group II: Group I + control group (n = 58) |  |  |  |  |
Chen 2010 [25] | 96 | 'Fufang Biejia Ruangan Tablets' + Entecavir (n = 46) | Entecavir (n = 50) | 1 year | HA, LN, PC-III & IV-C | ALT & AST. |
Dai 2011 [26] | 68 | 'Fufang Biejia Ruangan Tablets' + Entecavir (n = 34) | Entecavir (n = 34) | 1 year | HA, LN, PC-III & IV-C | ALT, AST & Improvement of related clinical symptoms |
Gao 2000 [34] | 120 | 'HB-Granule-3' (n = 60) | IFN-α (n = 60) | 90 days | HA, LN & IV-C | ALT & Improvement of related clinical symptoms |
Huang 2007 [27] | 99 | 'Decoction of Radix Salviae Milltorrhizae, Radix Astragali and Rhubarb' (n = 50) | IFN-α (n = 49) | 3 months | HA, LN, PC-III & IV-C | ALT & AST |
Huang 2009 [28] | 83 | 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 43) | Adefovir dipivoxil (n = 40) | 1 year | Â | ALT & AST |
Kuang 2005 [29] | 53 | Bie Jia Jian Decoction (n = 27) | LVD (n = 26) | 60 days | HA, PC-III & IV-C | ALT, AST & Improvement of related clinical symptoms |
Li 2006 [30] | 60 | 'Xiexian Oral Liquid' + conventional care (n = 30) | Placebo + conventional care (n = 30) | 4 months | HA, LN & IV-C | ALT, AST & Improvement of related clinical symptoms |
Li 2011 [31] | 88 | 'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 44) | Adefovir dipivoxil (n = 44) | 9 months | HA, LN, PC-III & IV-C | ALT & AST |
Lu 2010 [32] | 82 | 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 42) | Adefovir dipivoxil (n = 40) | 1 year | HA, LN, PC-III & IV-C | ALT, AST & Improvement of related clinical symptoms |
Shen 2003 [35] | 68 | 'Ganxian Prescirption' + LVD (n = 31) | LVD (n = 37) | 1 year | HA, LN & IV-C | ALT & AST |
Shen 2005 [21] | 120 | Group I: 'Ganxian Recipe' (n = 40) | LVD (n = 40) | 2 years | HA, LN & IV-C | ALT & AST |
 |  | Group II: 'Ganxian Recipe' + LVD |  |  |  |  |
 |  | (n = 40) |  |  |  |  |
Sun 2010 [36] | 55 | 'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 30) | Adefovir dipivoxil (n = 25) | 48 weeks | HA, LN, PC-III & IV-C | ALT, AST & Improvement of related clinical symptoms. |
Wang 2006 [23] | 160 | Group I: experienced clinical decoction (n = 50) | LVD (n = 50) | 6 months | HA, LN, PC-III & IV-C | Â |
 |  | Group II: Group I + Control Group (n = 60) |  |  |  |  |
Wang 2010 [37] | 98 | 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 49) | Adefovir dipivoxil (n = 49) | 1 year | HA, LN, PC-III & IV-C | ALT |
Wei 2010 [38] | 44 | 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 22) | Adefovir dipivoxil (n = 22) | 1 year | HA, LN, PC-III & IV-C | ALT & AST |
Xie 2009 [39] | 62 | 'Huaxian Fugan Prescription' + conventional care (n = 32) | Conventional care (n = 30) | 6 months | HA, LN, PC-III & IV-C | ALT, AST & Improvement of related clinical symptoms |
Yang 2009 [40] | 120 | 'Fufang Biejia Ruangan Tablets' + LVD + conventional care (n = 60) | LVD + conventional care (n = 60) | 6 months | HA, LN, PC-III & IV-C | ALT & AST |
Yin 2004 [41] | 102 | 'Herbal Compound 861' (n = 52) | Placebo (n = 50) | 24 weeks | HA, LN, PC-III, IV-C, MMPI, MMP2, MMP9, TIMPI & TIMP2 | ALT, AST & Improvement of related clinical symptoms |
Zhang 2000 [42] | 78 | 'Kanggan Xianfang' + conventional care (n = 39) | Conventional care (n = 39) | 6 months | HA, PC-III & TGF-β1 | ALT & Improvement of related clinical symptoms |