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Table 1 Characteristics of the included studies

From: Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

Study ID

Sample size

Intervention Group

Control Group

Duration Primary Outcomes

Secondary Outcomes

Chen 2005 [24]

49

'Fufang Biejia Ruangan Tablets' + IFN-γ (n = 28)

IFN-γ (n = 21)

6 months

HA, LN, PC-III, IV-C & Knodell score

ALT & AST

Chen 2006 [33]

116

Kang Xian Decoction + IFN-α (n = 58)

IFN-α (n = 58)

6 months

HA, LN & PC-III

ALT & Improvement of related clinical symptoms

Chen 2006_2 [20]

138

'Qianggan Capsule' + conventional care (n = 68)

Placebo + conventional care (n = 70)

6 months

HA, LN, PC-III & IV-C

ALT, Improvement of related clinical symptoms

Chen 2007 [22]

164

Group I: Bie Jia Jian Pills + conventional care (n = 54)

IFN + conventional care (n = 52)

9 months

HA, LN & PC-III

 
  

Group II: Group I + control group (n = 58)

    

Chen 2010 [25]

96

'Fufang Biejia Ruangan Tablets' + Entecavir (n = 46)

Entecavir (n = 50)

1 year

HA, LN, PC-III & IV-C

ALT & AST.

Dai 2011 [26]

68

'Fufang Biejia Ruangan Tablets' + Entecavir (n = 34)

Entecavir (n = 34)

1 year

HA, LN, PC-III & IV-C

ALT, AST & Improvement of related clinical symptoms

Gao 2000 [34]

120

'HB-Granule-3' (n = 60)

IFN-α (n = 60)

90 days

HA, LN & IV-C

ALT & Improvement of related clinical symptoms

Huang 2007 [27]

99

'Decoction of Radix Salviae Milltorrhizae, Radix Astragali and Rhubarb' (n = 50)

IFN-α (n = 49)

3 months

HA, LN, PC-III & IV-C

ALT & AST

Huang 2009 [28]

83

'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 43)

Adefovir dipivoxil (n = 40)

1 year

 

ALT & AST

Kuang 2005 [29]

53

Bie Jia Jian Decoction (n = 27)

LVD (n = 26)

60 days

HA, PC-III & IV-C

ALT, AST & Improvement of related clinical symptoms

Li 2006 [30]

60

'Xiexian Oral Liquid' + conventional care (n = 30)

Placebo + conventional care (n = 30)

4 months

HA, LN & IV-C

ALT, AST & Improvement of related clinical symptoms

Li 2011 [31]

88

'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 44)

Adefovir dipivoxil (n = 44)

9 months

HA, LN, PC-III & IV-C

ALT & AST

Lu 2010 [32]

82

'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 42)

Adefovir dipivoxil (n = 40)

1 year

HA, LN, PC-III & IV-C

ALT, AST & Improvement of related clinical symptoms

Shen 2003 [35]

68

'Ganxian Prescirption' + LVD (n = 31)

LVD (n = 37)

1 year

HA, LN & IV-C

ALT & AST

Shen 2005 [21]

120

Group I: 'Ganxian Recipe' (n = 40)

LVD (n = 40)

2 years

HA, LN & IV-C

ALT & AST

  

Group II: 'Ganxian Recipe' + LVD

    
  

(n = 40)

    

Sun 2010 [36]

55

'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 30)

Adefovir dipivoxil (n = 25)

48 weeks

HA, LN, PC-III & IV-C

ALT, AST & Improvement of related clinical symptoms.

Wang 2006 [23]

160

Group I: experienced clinical decoction (n = 50)

LVD (n = 50)

6 months

HA, LN, PC-III & IV-C

 
  

Group II: Group I + Control Group (n = 60)

    

Wang 2010 [37]

98

'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 49)

Adefovir dipivoxil (n = 49)

1 year

HA, LN, PC-III & IV-C

ALT

Wei 2010 [38]

44

'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 22)

Adefovir dipivoxil (n = 22)

1 year

HA, LN, PC-III & IV-C

ALT & AST

Xie 2009 [39]

62

'Huaxian Fugan Prescription' + conventional care (n = 32)

Conventional care (n = 30)

6 months

HA, LN, PC-III & IV-C

ALT, AST & Improvement of related clinical symptoms

Yang 2009 [40]

120

'Fufang Biejia Ruangan Tablets' + LVD + conventional care (n = 60)

LVD + conventional care (n = 60)

6 months

HA, LN, PC-III & IV-C

ALT & AST

Yin 2004 [41]

102

'Herbal Compound 861' (n = 52)

Placebo (n = 50)

24 weeks

HA, LN, PC-III, IV-C, MMPI, MMP2, MMP9, TIMPI & TIMP2

ALT, AST & Improvement of related clinical symptoms

Zhang 2000 [42]

78

'Kanggan Xianfang' + conventional care (n = 39)

Conventional care (n = 39)

6 months

HA, PC-III & TGF-β1

ALT & Improvement of related clinical symptoms