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Table 1 Characteristics of the included studies

From: Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials

Study ID Sample size Intervention Group Control Group Duration Primary Outcomes Secondary Outcomes
Chen 2005 [24] 49 'Fufang Biejia Ruangan Tablets' + IFN-γ (n = 28) IFN-γ (n = 21) 6 months HA, LN, PC-III, IV-C & Knodell score ALT & AST
Chen 2006 [33] 116 Kang Xian Decoction + IFN-α (n = 58) IFN-α (n = 58) 6 months HA, LN & PC-III ALT & Improvement of related clinical symptoms
Chen 2006_2 [20] 138 'Qianggan Capsule' + conventional care (n = 68) Placebo + conventional care (n = 70) 6 months HA, LN, PC-III & IV-C ALT, Improvement of related clinical symptoms
Chen 2007 [22] 164 Group I: Bie Jia Jian Pills + conventional care (n = 54) IFN + conventional care (n = 52) 9 months HA, LN & PC-III  
   Group II: Group I + control group (n = 58)     
Chen 2010 [25] 96 'Fufang Biejia Ruangan Tablets' + Entecavir (n = 46) Entecavir (n = 50) 1 year HA, LN, PC-III & IV-C ALT & AST.
Dai 2011 [26] 68 'Fufang Biejia Ruangan Tablets' + Entecavir (n = 34) Entecavir (n = 34) 1 year HA, LN, PC-III & IV-C ALT, AST & Improvement of related clinical symptoms
Gao 2000 [34] 120 'HB-Granule-3' (n = 60) IFN-α (n = 60) 90 days HA, LN & IV-C ALT & Improvement of related clinical symptoms
Huang 2007 [27] 99 'Decoction of Radix Salviae Milltorrhizae, Radix Astragali and Rhubarb' (n = 50) IFN-α (n = 49) 3 months HA, LN, PC-III & IV-C ALT & AST
Huang 2009 [28] 83 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 43) Adefovir dipivoxil (n = 40) 1 year   ALT & AST
Kuang 2005 [29] 53 Bie Jia Jian Decoction (n = 27) LVD (n = 26) 60 days HA, PC-III & IV-C ALT, AST & Improvement of related clinical symptoms
Li 2006 [30] 60 'Xiexian Oral Liquid' + conventional care (n = 30) Placebo + conventional care (n = 30) 4 months HA, LN & IV-C ALT, AST & Improvement of related clinical symptoms
Li 2011 [31] 88 'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 44) Adefovir dipivoxil (n = 44) 9 months HA, LN, PC-III & IV-C ALT & AST
Lu 2010 [32] 82 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 42) Adefovir dipivoxil (n = 40) 1 year HA, LN, PC-III & IV-C ALT, AST & Improvement of related clinical symptoms
Shen 2003 [35] 68 'Ganxian Prescirption' + LVD (n = 31) LVD (n = 37) 1 year HA, LN & IV-C ALT & AST
Shen 2005 [21] 120 Group I: 'Ganxian Recipe' (n = 40) LVD (n = 40) 2 years HA, LN & IV-C ALT & AST
   Group II: 'Ganxian Recipe' + LVD     
   (n = 40)     
Sun 2010 [36] 55 'Anluo Huaxian Pills' + Adefovir dipivoxil (n = 30) Adefovir dipivoxil (n = 25) 48 weeks HA, LN, PC-III & IV-C ALT, AST & Improvement of related clinical symptoms.
Wang 2006 [23] 160 Group I: experienced clinical decoction (n = 50) LVD (n = 50) 6 months HA, LN, PC-III & IV-C  
   Group II: Group I + Control Group (n = 60)     
Wang 2010 [37] 98 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 49) Adefovir dipivoxil (n = 49) 1 year HA, LN, PC-III & IV-C ALT
Wei 2010 [38] 44 'Fufang Biejia Ruangan Tablets' + Adefovir dipivoxil (n = 22) Adefovir dipivoxil (n = 22) 1 year HA, LN, PC-III & IV-C ALT & AST
Xie 2009 [39] 62 'Huaxian Fugan Prescription' + conventional care (n = 32) Conventional care (n = 30) 6 months HA, LN, PC-III & IV-C ALT, AST & Improvement of related clinical symptoms
Yang 2009 [40] 120 'Fufang Biejia Ruangan Tablets' + LVD + conventional care (n = 60) LVD + conventional care (n = 60) 6 months HA, LN, PC-III & IV-C ALT & AST
Yin 2004 [41] 102 'Herbal Compound 861' (n = 52) Placebo (n = 50) 24 weeks HA, LN, PC-III, IV-C, MMPI, MMP2, MMP9, TIMPI & TIMP2 ALT, AST & Improvement of related clinical symptoms
Zhang 2000 [42] 78 'Kanggan Xianfang' + conventional care (n = 39) Conventional care (n = 39) 6 months HA, PC-III & TGF-β1 ALT & Improvement of related clinical symptoms