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Table 1 Beneficial effects of SA-B and propranolol on MI biomarkers

From: Metabolomic profiles of myocardial ischemia under treatment with salvianolic acid B

Biomarkers Sham group MI group SA-B group Propranolol group P value
  Mean ± SD a Mean ± SD Mean ± SD Mean ± SD SA-B vs . MI Propranolol vs . MI
Allantoin 23.87 ± 4.14 0.00 ± 0.00 20.32 ± 5.36 23.16 ± 8.17 0.000 0.000
1-Phenylethylamine 4.13 ± 1.88 23.66 ± 1.33 12.61 ± 0.96 9.42 ± 1.36 0.001 0.000
Hypoxanthine 0.00 ± 0.00 14.72 ± 14.01 6.68 ± 2.86 0.00 ± 0.00 0.001 0.000
L-Valine 37.98 ± 3.80 13.17 ± 2.14 22.75 ± 4.25 29.41 ± 6.31 0.002 0.001
L-Isoleucine 122.84 ± 21.91 39.18 ± 2.37 92.59 ± 12.26 139.28 ± 26.48 0.001 0.000
Carnosine 16.18 ± 2.70 0.00 ± 0.00 22.13 ± 04.27 19.35 ± 2.34 0.000 0.000
L-isoleucyl-L-Proline 28.69 ± 3.90 79.23 ± 21.02 52.15 ± 14.06 41.32 ± 20.49 0.027 0.011
Phytosphingosine 16.74 ± 1.89 82.93 ± 10.12 32.17 ± 6.29 41.38 ± 5.44 0.000 0.000
Dihydrosphingosine 26.02 ± 0.99 146.98 ± 15.82 52.18 ± 11.40 31.37 ± 7.14 0.001 0.000
2',3'-Cyclic GMP 6.30 ± 0.81 37.05 ± 5.97 15.16 ± 3.49 11.32 ± 2.40 0.001 0.000
2',3'-Cyclic AMP 30.33 ± 1.78 190.63 ± 16.91 153.21 ± 19.48 51.43 ± 8.46 0.008 0.000
Dihydrobiopterin 42.64 ± 4.78 8.23 ± 3.82 19.18 ± 8.31 39.27 ± 8.19 0.015 0.000
Xanthine 0.00 ± 0.00 25.94 ± 6.39 24.13 ± 7.51 0.00 ± 0.00 0.805 0.000
Inosine 0.00 ± 0.00 12.84 ± 3.49 12.03 ± 0.89 0.00 ± 0.00 0.913 0.000
Glyceraldehyde 189.71 ± 13.83 31.23 ± 2.72 99.30 ± 9.47 159.29 ± 12.69 0.000 0.000
L-Phenylalanine 14.65 ± 4.69 0.00 ± 0.00 5.34 ± 2.06 9.28 ± 2.44 0.000 0.000
L-Tryptophan 64.74 ± 12.98 20.06 ± 1.15 77.27 ± 2.40 59.45 ± 5.46 0.000 0.000
2-oxoisocaproic acid 27.85 ± 3.98 6.13 ± 1.23 17.33 ± 3.54 29.75 ± 4.94 0.000 0.000
5-Phosphoribosylamine 87.81 ± 4.96 211.14 ± 15.24 203.47 ± 10.26 129.32 ± 24.94 0.871 0.002
15(S)-HETE 0.00 ± 0.00 243.89 ± 99.98 71.67 ± 4.40 0.00 ± 0.00 0.001 0.000
Thromboxane B2 2.87 ± 1.95 18.27 ± 2.92 11.03 ± 0.64 9.42 ± 3.38 0.002 0.001
  1. a Mean peak areas of MI biomarkers in different groups were calculated to reveal the beneficial effects of SA-B and propranolol; SD denotes standard deviation.