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Table 2 Comparisons of the treatment (Black cohosh) and control (placebo) groups in terms of the Greene climacteric scale total and subscale scores at baseline and two follow-up time-points

From: Efficacy of black cohosh (Cimicifuga racemosa L.) in treating early symptoms of menopause: a randomized clinical trial

Outcome variables

Treatment (n = 42) Mean ± SD

Control (n = 42) Mean ± SD

Comparison of the groups

   

Adjusted MD (95%CI)

P

Partial Eta2

Total score (0–63)

     

Baseline

33.8 ± 6.4

31.1 ± 6.3

2.7 (-0.1 to 5.4)

0.059

 

4 weeks

16.7 ± 7.7

22.9 ± 9.2

-7.8 (-11.1 to -4.4)

< 0.001

0.21

8 weeks

8.0 ± 5.5

19.5 ± 11.0

-12.9 (-16.2 to -9.3)

< 0.001

0.39

Vasomotor symptoms (0–6)

     

Baseline

4.0 ± 1.7

3.5 ± 1.6

0.5 (-2.9 to 1.2)

0.22

 

4 weeks

1.8 ± 2.0

2.6 ± 1.7

-1.1 (-0.4 to -1.8)

0.002

0.11

8 weeks

0.7 ± 1.6

2.4 ± 1.8

-1.9 (-1.2 to -2.6)

< 0.001

0.26

Psychiatric symptoms (0–33)

     

Baseline

18.8 ± 4.8

18.8 ± 4.3

0.1 (-2.1 to 1.9)

0.92

 

4 weeks

10.8 ± 5.0

13.3 ± 6.4

-2.6 (-0.3 to -4.9)

< 0.001

0.16

8 weeks

4.2 ± 3.5

11.4 ± 7.4

-7.3 (-9.6 to -5.0)

< 0.001

0.31

Physical symptoms (0–21)

     

Baseline

7.7 ± 3.5

6.6 ± 2.7

1.1 (-0.3 to 2,5)

0.10

 

4 weeks

3.1 ± 2.3

4.7 ± 2.8

-2.0 (-3.1 to -1.0)

< 0.001

0.06

8 weeks

1.4 ± 1.5

3.7 ± 2.4

-2.5 (-3.3 to -1.7)

< 0.001

0.33

Loss of interest in sex (0–3)

     

Baseline

2.6 ± 0.8

2.4 ± 1.4

0.2 (-0.7 to 0.3)

0.47

 

4 weeks

1.8 ± 1.0

1.9 ± 1.0

-0.37 (-0.72 to -0.03)

0.03

0.06

8 weeks

1.6 ± 1.1

1.9 ± 1.0

-0.52 (-0.89 to -0.15)

0.006

0.09