Figure 5

Photomicrographs of paraffin-embedded rat liver. Each sample was pretreated for 7 days and then treated with a single dose of CCl₄. (A) untreated group (group I); (B) CCl₄ alone (group II); (C) silymarin (50 mg/kg BW, group III); (D) HCIF (50 mg/kg BW, group IV); (E) HCIF (100 mg/kg BW, group V); (F) tea seed oil (200 mg/kg BW, group VI). All hepatotoxicity was induced in rats with 1 mg/kg body weight of CCl₄ and analyzed 24 h later. Each of the arrows indicated vacuole formation (a), necrosis (b) and fatty degeneration (c).