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Table 1 The role of Chinese herbs and its active ingredients on proliferation and differentiation of neural stem cells in vivo

From: Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells

Chinese herbs and active ingredients Animal model Sites of neural stem cells The role of proliferation The role of differntiation
Acanthopanax[22, 23] Transient global cerebral ischemia in rats Hippocampus, ependymal, subependymal region, ischemic area Nestin positive cells↑  
Angelica[24, 25] The intrauterine hypoxia embryonic rats Whole brain Nestin positive cells↑  
Rhodiola[26, 27] Chronic stress rats Hippocampus BrdU positive cells↑ BrdU/β-tubulin ↑. Neuronal directed differentiation
Ganoderma spore[26, 28] Spinal cord injury in rats Central canal ependymal zone BrdU positive cells↑ BrdU/NF; BrdU/GFAP; BrdU/Oligo↑
Polygala[29, 31] Mouse AD model (D-galactose + sodium nitrite intraperitoneal injection) SGZ BrdU positive cells↑  
Tetramethylpyrazine[32] Ischemia-reperfusion of cerebral ischemia in rats SGZ BrdU positive cells↑  
Gardenia[33] Chronically stressed mice SGZ BrdU positive cells↑  
Astragaloside[32, 34, 35] Transient forebrain ischemia in rats CA1 of hippocampus, SGZ BrdU positive cells↑ BrdU/MAP-2; BrdU/GFAP; ↑
Ginsenoside Rg1[19, 32, 3640] MCAO rats SVZ, SGZ, CA1 of hippocampus Nestin, BrdU and nestin/BrdU positive cells↑  
Panax notoginseng saponins[19, 3639] MCAO rats SVZ, Hippocampus and cortex Nestin positive cells↑ Nestin/GFAP↑
  Cortical devascularization rats SVZ Nestin positive cells↑