Table 1 The role of Chinese herbs and its active ingredients on proliferation and differentiation of neural stem cells in vivo
Chinese herbs and active ingredients | Animal model | Sites of neural stem cells | The role of proliferation | The role of differntiation |
|---|---|---|---|---|
Transient global cerebral ischemia in rats | Hippocampus, ependymal, subependymal region, ischemic area | Nestin positive cells↑ | ||
The intrauterine hypoxia embryonic rats | Whole brain | Nestin positive cells↑ | ||
Chronic stress rats | Hippocampus | BrdU positive cells↑ | BrdU/β-tubulin ↑. Neuronal directed differentiation | |
Spinal cord injury in rats | Central canal ependymal zone | BrdU positive cells↑ | BrdU/NF; BrdU/GFAP; BrdU/Oligo↑ | |
Mouse AD model (D-galactose + sodium nitrite intraperitoneal injection) | SGZ | BrdU positive cells↑ | ||
Tetramethylpyrazine[32] | Ischemia-reperfusion of cerebral ischemia in rats | SGZ | BrdU positive cells↑ | |
Gardenia[33] | Chronically stressed mice | SGZ | BrdU positive cells↑ | |
Transient forebrain ischemia in rats | CA1 of hippocampus, SGZ | BrdU positive cells↑ | BrdU/MAP-2; BrdU/GFAP; ↑ | |
MCAO rats | SVZ, SGZ, CA1 of hippocampus | Nestin, BrdU and nestin/BrdU positive cells↑ | ||
MCAO rats | SVZ, Hippocampus and cortex | Nestin positive cells↑ | Nestin/GFAP↑ | |
Cortical devascularization rats | SVZ | Nestin positive cells↑ |