Table 2 The role of Chinese herbs and its active ingredients on proliferation and differentiation of neural stem cells in vitro
Chinese herbs and active ingradients | Types of neural stem cells | The role of proliferation | The role of differentiation | Mechanism |
|---|---|---|---|---|
14d cortical NSCs of embryonic rats | NF and GFAP positive cells↑ | |||
Musk[43] | 14d striatal NSCs of embryonic rats | Electrotransfer rate of pEGFP-C1↑Glial-like cell directed differentiation | ||
Baicalin[44] | Cortical NSCs of embryonic rats | β-tubulin and MAP-2 positive cells↑ ↑ | ||
Geniposide[19] | Cortical NSCs of embryonic rats | β-tubulin positive cells↑ | ||
Baicalin + astragaloside,[45] Baicalin + P. notoginseng saponins[38] | Cortical NSCs of embryonic rats | Expression of Tau↑ (adults neurons) | ||
Hippocampal NSCs of Neonatal rat, E14 SVZ NSCs of embryonic rats | NF cells (Has nothing to do with the concentration) ↑, GFAP cells (Positively correlated with the concentration) ↑ | |||
SVZ NSCs of adult rats | MAP-2 cells↑ | |||
SVZ NSCs of neonatal mice | β-tubulin and GFAP cells↑ | |||
Cili polysaccharide[48] | 14d embryonic rat striatal NSCs (glutamic acid damage) | Protection. Cell death rate↓; lactate dehydrogenase leakage rate↓ | ||
Salidroside[34] | Hippocampal NSCs of neonatal rats | NSE cells↑ | ||
Quercetin-3-O-celery glucoside (CTN-986)[49] | Hippocampal NSCs of neonatal rats | MTT↑ | ||
3H-TdR intake↑ | ||||
14d cortical NSCs of embryonic rats | NSCs↑ | The expression of Hes5 and Cyclin D1↑ | ||
Antler polypeptides[50] | 14d cortical NSCs of embryonic rats | NSE cells↑ | ||
14d cortical NSCs of embryonic rats | BrdU cells↑ | The expression of Hes1 and Mash1↑ | ||
TSPG[53] | Human embryonic NSCs | MTT↑ | Directed differentiation of DA neuron | |
E17 cortical and hippocampal NSCs of neonatal rats | Nestin and PCNA cells↑ | Tuj1, NF, vimentin and GFAP cells↑ | The expression of BDNF and bFGF↑ |