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Table 2 The role of Chinese herbs and its active ingredients on proliferation and differentiation of neural stem cells in vitro

From: Chinese herbs and their active ingredients for activating xue (blood) promote the proliferation and differentiation of neural stem cells and mesenchymal stem cells

Chinese herbs and active ingradients Types of neural stem cells The role of proliferation The role of differentiation Mechanism
Astragalus[41, 42] 14d cortical NSCs of embryonic rats   NF and GFAP positive cells↑  
Musk[43] 14d striatal NSCs of embryonic rats   Electrotransfer rate of pEGFP-C1↑Glial-like cell directed differentiation  
Baicalin[44] Cortical NSCs of embryonic rats   β-tubulin and MAP-2 positive cells↑ ↑  
Geniposide[19] Cortical NSCs of embryonic rats   β-tubulin positive cells↑  
Baicalin + astragaloside,[45] Baicalin + P. notoginseng saponins[38] Cortical NSCs of embryonic rats   Expression of Tau↑ (adults neurons)  
Ginkgolide B[34, 46, 47] Hippocampal NSCs of Neonatal rat, E14 SVZ NSCs of embryonic rats   NF cells (Has nothing to do with the concentration) ↑, GFAP cells (Positively correlated with the concentration) ↑  
SVZ NSCs of adult rats   MAP-2 cells↑  
SVZ NSCs of neonatal mice   β-tubulin and GFAP cells↑  
Cili polysaccharide[48] 14d embryonic rat striatal NSCs (glutamic acid damage)    Protection. Cell death rate↓; lactate dehydrogenase leakage rate↓
Salidroside[34] Hippocampal NSCs of neonatal rats   NSE cells↑  
Quercetin-3-O-celery glucoside (CTN-986)[49] Hippocampal NSCs of neonatal rats MTT↑   
3H-TdR intake↑
  14d cortical NSCs of embryonic rats NSCs↑   The expression of Hes5 and Cyclin D1↑
Antler polypeptides[50] 14d cortical NSCs of embryonic rats   NSE cells↑  
Ginsenoside Rg1[21, 40, 51, 52] 14d cortical NSCs of embryonic rats BrdU cells↑   The expression of Hes1 and Mash1↑
TSPG[53] Human embryonic NSCs MTT↑ Directed differentiation of DA neuron  
P. notoginseng saponins[39, 54] E17 cortical and hippocampal NSCs of neonatal rats Nestin and PCNA cells↑ Tuj1, NF, vimentin and GFAP cells↑ The expression of BDNF and bFGF↑