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Table 2 The major bio-functions of identified proteins

From: Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study

Protein name Protein symbol Subcellular location Protein functions Up/down regulation
Cell growth and cell cycle regulation
14-3-3 Gamma, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 14-3-3γ Cytoplasm G2 DNA damage checkpoint [37]
mitotic checkpoint protein BUB3 isoform A BUB3 Nucleus Spindle-assembly checkpoint signalling and establishment of correct kinetochore-microtubule attachments [38]
microtubule-associated protein RP/EB family member 1 MAPRE1 Cytoplasm Microtubule polymerization [39]
Dynactin subunit 2 DCTN2 Cytoplasm Modulates cytoplasmic dynein binding to an organelle, and prometaphase chromosome alignment and spindle organization during mitosis [40]
thioredoxin-like protein GLRX3 Cytoplasm Human cancer cell growth and metastasis regulation [41]
Chloride intracellular channel protein 1 CLIC1 Nucleus membrane, cell membrane Formation of chloride ion channels, and regulation of the cell cycle [42]
Anti-cancer effects
ectonucleoside triphosphate diphosphohydrolase 5, isoform ENTPD5 Endoplasmic reticulum lumen Promoting glycolysis in proliferating cells in response to phosphoinositide 3-kinase signalling in the AKT1-PTEN signalling pathway [43]
N-myc downstream regulated gene 1 NDRG1 Cytoplasm, nucleus, cell membrane Metastasis suppression [44]
heat shock protein beta-1 HSPB1 Cytoplasm, nucleus Stress resistance and actin organization [45]
alpha-enolase isoform 1 ENO1 Cytoplasm, cell membrane Multifunctional enzyme in various processes such as growth control, hypoxia tolerance and allergic responses [46]
Other functions
xaa-Pro dipeptidase isoform 3 PEPD Cytoplasm Collagen and GSH metabolism [47]
Enoyl-CoA delta isomerase 1, mitochondrial ECI1 Mitochondrion matrix  
The Protein-Disulfide Isomerase Related Chaperone Erp29 ERP29 Endoplasmic reticulum lumen Processing of secretory proteins within the endoplasmic reticulum, possibly by participating in the folding of proteins in the ER [48]
phosphatidylinositol transfer protein beta isoform PITPNB Cytoplasm, Golgi apparatus Catalyzes the transfer of PtdIns and phosphatidylcholine between membranes [49]
hnRNP 2H9B HNRNPH3 Nucleus Involved in the splicing process and participates in early heat shock-induced splicing arrest [50]
WD repeat-containing protein 1 isoform 1 WDR1 Cytoplasm Induces disassembly of actin filaments in conjunction with ADF/cofilin family proteins [51]
peroxiredoxin 1 PRDX1 Cytoplasm Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system but not from glutaredoxin [52]
WD-40 repeat protein, serine/threonine kinase receptor associated protein STRAP Cytoplasm, nucleus The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus [53, 54]