Table 3 Canonical pathways induced by frankincense and sandalwood essential oils treatment
Canonical pathways | Unique to frankincense oil | Common genes | Unique to sandalwood oil |
|---|---|---|---|
Aryl hydrocarbon receptor signaling (6.61E-05) | AHR, CDKN1A, FOS, IL1A, IL6, JUN, MYC | --- | --- |
NRF2-mediated oxidative stress response (1.58E-03) | DNAJA4, DNAJB1, DNAJB4, FOS, JUN, JUNB | --- | --- |
ATM signaling (1.74E-05) | --- | --- | CDKN1A, GADD45A, GADD45B, JUN, RAD50, TLK1 |
p38 MAPK signaling (6.92E-06 - 7.94E-05) | JMJD7-PLA2G4B | DDIT3, DUSP1, DUSP10, IL1A, IRAK2, MYC | HIST2H3D |
p53 signaling (2.75E-02 - 3.98E-04) | PRKDC | CDKN1A, JUN | CASP6, GADD45A, GADD45B, PMAIP1 |
IL-6 signaling (5.25E-05 - 4.17E-04) | FOS | IL1A, IL6, IL6ST, IL8, JUN | CEBPB |
HMGB1 signaling (5.89E-04 - 3.16E-03) | FOS | IL1A, IL8, JUN, RND3 | RAGE |