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Table 3 Effects of the B. marginatum extracts on viral replication using direct plaque reduction assays

From: Anti-infective and cytotoxic properties of Bupleurum marginatum

  % inhibition in viral replication
HSV-1 HAV VSV
CH 3 OH extract  
 6.25 μg/mL 21.75 ± 1.18 33.71 ± 1.82 12.87 ± 1.88
 12.50 μg/mL 56.44 ± 1.60 65.01 ± 2.12 41.37 ± 2.16
 50.00 μg/mL 66.26 ± 2.72 (P* = 0.0011)a 76.56 ± 4.29 (P* = 0.025)b 56.59 ± 2.03 (P* = 0.0024)c
CH 2 Cl 2 extract  
 6.25 μg/mL 29.45 ± 1.23 42.51 ± 2.21 39.27 ± 1.95
 12.50 μg/mL 59.53 ± 3.41 73.67 ± 3.03 69.55 ± 3.16
 50.00 μg/mL 73.91 ± 4.13 (P* = 0.0017)a 81.42 ± 6.15 (P* = 0.019)b 79.96 ± 4.51 (P* = 0.0009)c
  1. Data are presented as means ± SD (n = 3).
  2. HSV-1: herpes simplex virus type-1; HAV: hepatitis A virus; VSV: vesicular stomatitis virus.
  3. P*: Significant difference relative to acyclovir.
  4. aSignificant difference at P = 0.048.
  5. bSignificant different at P = 0.037.
  6. cSignificant difference at P = 0.001.