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Table 3 Effects of the B. marginatum extracts on viral replication using direct plaque reduction assays

From: Anti-infective and cytotoxic properties of Bupleurum marginatum

 

% inhibition in viral replication

HSV-1

HAV

VSV

CH 3 OH extract

 

 6.25 μg/mL

21.75 ± 1.18

33.71 ± 1.82

12.87 ± 1.88

 12.50 μg/mL

56.44 ± 1.60

65.01 ± 2.12

41.37 ± 2.16

 50.00 μg/mL

66.26 ± 2.72 (P* = 0.0011)a

76.56 ± 4.29 (P* = 0.025)b

56.59 ± 2.03 (P* = 0.0024)c

CH 2 Cl 2 extract

 

 6.25 μg/mL

29.45 ± 1.23

42.51 ± 2.21

39.27 ± 1.95

 12.50 μg/mL

59.53 ± 3.41

73.67 ± 3.03

69.55 ± 3.16

 50.00 μg/mL

73.91 ± 4.13 (P* = 0.0017)a

81.42 ± 6.15 (P* = 0.019)b

79.96 ± 4.51 (P* = 0.0009)c

  1. Data are presented as means ± SD (n = 3).
  2. HSV-1: herpes simplex virus type-1; HAV: hepatitis A virus; VSV: vesicular stomatitis virus.
  3. P*: Significant difference relative to acyclovir.
  4. aSignificant difference at P = 0.048.
  5. bSignificant different at P = 0.037.
  6. cSignificant difference at P = 0.001.