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Table 4 Cytotoxicities of the B. marginatum extracts (IC 50 values; μg/ml) after 24 h of incubation

From: Anti-infective and cytotoxic properties of Bupleurum marginatum

Cell lines Methanol extract (μg/mL) Dichloromethane extract (μg/mL) P1value
Caco-2 108.44 ± 11.43 (P* = 0.012) 56.81 ± 6.30 (P* = 0.009) 0.0011
CCRF-CEM 22.75 ± 2.76 (P* = 0.014) 12.54 ± 1.87 (P* = 0.004) 0.0335
CCL-81 307.51 ± 13.76 (P* = 0.007) 72.81 ± 6.15 (P* = 0.013) 0.0016
COS-7 576.0 ± 11.65 (P* = 0.009) 67.40 ± 2.76 (P* = 0.021) 0.0019
HL-60 100.88 ± 4.02 (P* = 0.021) 35.07 ± 2.28 (p* = 0.007) 0.0026
MIA PaCa-2 22.51 ± 2.98 (P* = 0.023) 14.98 ± 1.09 (P* = 0.018) 0.0388
MCF-7 91.18 ± 8.99 (P* = 0.011) 51.00 ± 5.20 (P* = 0.041) 0.0279
PANC-1 34.81 ± 3.01 (P* = 0.031) 27.62 ± 2.96 (P* = 0.022) 0.0281
  1. Data are presented as means ± SD (n = 3).
  2. P*: Significant difference relative to doxorubicin.
  3. P1: Significant difference relative to each other.