Table 2 Inhibitory mechanisms of extracellular matrix deposition via medicinal plants

C. longa[6],[30],[32],[34],[36],[37],[42]-[44],[46],[149]-[159]

Curcumin

Collagen type I; collagen type III; fibronectin; hyaluronic acid; laminin

MMP-2; MMP-9; MMP-13; MMP-7

TIMP-1; TIMP-2

_

S. marianum[47],[48],[50],[51],[160]-[165]

Silymarin; silibinin (silybin)

Collagen type I; collagen type III

_

TIMP-1; TIMP-2

_

G. biloba[55]-[59],[166]-[169]

G. biloba extract; EGb761

Collagen type I; collagen type III; laminin; hyaluronic acid; collagen type IV

MMP-1

TIMP-1

_

S. miltiorrhiza[46],[49],[65],[66],[75]-[91],[94],[96],[98],[99],[170]-[179]

Salvianolic acid A; salvianolic acid B; salvianic acid A; salianic acid B; IH764-3; magnesium; lithospermate B; tanshinone IIA; SMND-309

Collagen type I; collagen type III; hyaluronic acid; collagen type IV; laminin

MMP-13

TIMP-1

↓ PAI-1^d; ↑ uPA^e

G. glabra[102]-[104],[180],[181]

Glycyrrhizin; glycyrrhetinic acid; glycyrrhizic acid

Collagen type I; collagen type III

MMP-9

_

_

S. baicalensis[105],[106]

Baicalin

Collagen type I; collagen type III; hyaluronic acid collagen type IV

_

TIMP-1

_

B. falcatum[32],[108],[182]

Saikosaponin A; saikosaponin D

Collagen type I; hyaluronic acid; collagen type IV; laminin

_

_

_

Phyllanthus species [111],[183]

P. amarus extract; ethanol extract of P. niruri

Collagen type I

MMPs

TIMPs

_

B. aristata[114]

berberine

_

MMP-2

_

_

P. notoginseng[105],[115],[117],[118],[184],[185]

P. notoginseng saponins; ginsenoside Rb1; red ginseng extract; 25-OCH₃-PPD

Collagen type I; collagen type III; hyaluronic acid; collagen type IV

MMP-13

TIMP-1

↓ PAI-I^d

Coffea species [122],[124]-[126],[128],[186]-[189]

Decaffeinated coffee; normal coffee; 1,7-dimethylxanthine; caffeine; chlorogenic acid

Collagen type I

_

_

_

Collagen type III