Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Florent Duval; Jorge E Moreno-Cuevas; María Teresa González-Garza; Carlos Rodríguez-Montalvo; Delia Elva Cruz-Vega

doi:10.1186/s13020-014-0027-4

Table 2 Inhibitory mechanisms of extracellular matrix deposition via medicinal plants

From: Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Medicinal plants	Bioactive compounds/extracts	Mechanisms of reduction in ECM deposition
Medicinal plants	Bioactive compounds/extracts	↓ECM^aproteins	↑MMPs^b	↓TIMPs^c	Plasminogen activation system
C. longa[6],[30],[32],[34],[36],[37],[42]-[44],[46],[149]-[159]	Curcumin	Collagen type I; collagen type III; fibronectin; hyaluronic acid; laminin	MMP-2; MMP-9; MMP-13; MMP-7	TIMP-1; TIMP-2	_
S. marianum[47],[48],[50],[51],[160]-[165]	Silymarin; silibinin (silybin)	Collagen type I; collagen type III	_	TIMP-1; TIMP-2	_
G. biloba[55]-[59],[166]-[169]	G. biloba extract; EGb761	Collagen type I; collagen type III; laminin; hyaluronic acid; collagen type IV	MMP-1	TIMP-1	_
S. miltiorrhiza[46],[49],[65],[66],[75]-[91],[94],[96],[98],[99],[170]-[179]	Salvianolic acid A; salvianolic acid B; salvianic acid A; salianic acid B; IH764-3; magnesium; lithospermate B; tanshinone IIA; SMND-309	Collagen type I; collagen type III; hyaluronic acid; collagen type IV; laminin	MMP-13	TIMP-1	↓ PAI-1^d; ↑ uPA^e
G. glabra[102]-[104],[180],[181]	Glycyrrhizin; glycyrrhetinic acid; glycyrrhizic acid	Collagen type I; collagen type III	MMP-9	_	_
S. baicalensis[105],[106]	Baicalin	Collagen type I; collagen type III; hyaluronic acid collagen type IV	_	TIMP-1	_
B. falcatum[32],[108],[182]	Saikosaponin A; saikosaponin D	Collagen type I; hyaluronic acid; collagen type IV; laminin	_	_	_
Phyllanthus species [111],[183]	P. amarus extract; ethanol extract of P. niruri	Collagen type I	MMPs	TIMPs	_
B. aristata[114]	berberine	_	MMP-2	_	_
P. notoginseng[105],[115],[117],[118],[184],[185]	P. notoginseng saponins; ginsenoside Rb1; red ginseng extract; 25-OCH₃-PPD	Collagen type I; collagen type III; hyaluronic acid; collagen type IV	MMP-13	TIMP-1	↓ PAI-I^d
Coffea species [122],[124]-[126],[128],[186]-[189]	Decaffeinated coffee; normal coffee; 1,7-dimethylxanthine; caffeine; chlorogenic acid	Collagen type I	_	_	_
Coffea species [122],[124]-[126],[128],[186]-[189]		Collagen type III	_	_	_

↓: inhibitory effect, ↑: increased effect, ^aextracellular matrix, ^bmatrix metalloproteinase, ^ctissue inhibitor of metalloproteinase, ^dplasminogen activator inhibitor type 1, ^eurokinase-plasminogen activator.

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