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Table 2 Inhibitory mechanisms of extracellular matrix deposition via medicinal plants

From: Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosis

Medicinal plants Bioactive compounds/extracts Mechanisms of reduction in ECM deposition
↓ECMaproteins ↑MMPsb ↓TIMPsc Plasminogen activation system
C. longa[6],[30],[32],[34],[36],[37],[42]-[44],[46],[149]-[159] Curcumin Collagen type I; collagen type III; fibronectin; hyaluronic acid; laminin MMP-2; MMP-9; MMP-13; MMP-7 TIMP-1; TIMP-2 _
S. marianum[47],[48],[50],[51],[160]-[165] Silymarin; silibinin (silybin) Collagen type I; collagen type III _ TIMP-1; TIMP-2 _
G. biloba[55]-[59],[166]-[169] G. biloba extract; EGb761 Collagen type I; collagen type III; laminin; hyaluronic acid; collagen type IV MMP-1 TIMP-1 _
S. miltiorrhiza[46],[49],[65],[66],[75]-[91],[94],[96],[98],[99],[170]-[179] Salvianolic acid A; salvianolic acid B; salvianic acid A; salianic acid B; IH764-3; magnesium; lithospermate B; tanshinone IIA; SMND-309 Collagen type I; collagen type III; hyaluronic acid; collagen type IV; laminin MMP-13 TIMP-1 PAI-1d; uPAe
G. glabra[102]-[104],[180],[181] Glycyrrhizin; glycyrrhetinic acid; glycyrrhizic acid Collagen type I; collagen type III MMP-9 _ _
S. baicalensis[105],[106] Baicalin Collagen type I; collagen type III; hyaluronic acid collagen type IV _ TIMP-1 _
B. falcatum[32],[108],[182] Saikosaponin A; saikosaponin D Collagen type I; hyaluronic acid; collagen type IV; laminin _ _ _
Phyllanthus species [111],[183] P. amarus extract; ethanol extract of P. niruri Collagen type I MMPs TIMPs _
B. aristata[114] berberine _ MMP-2 _ _
P. notoginseng[105],[115],[117],[118],[184],[185] P. notoginseng saponins; ginsenoside Rb1; red ginseng extract; 25-OCH3-PPD Collagen type I; collagen type III; hyaluronic acid; collagen type IV MMP-13 TIMP-1 PAI-Id
Coffea species [122],[124]-[126],[128],[186]-[189] Decaffeinated coffee; normal coffee; 1,7-dimethylxanthine; caffeine; chlorogenic acid Collagen type I _ _ _
Collagen type III
  1. : inhibitory effect, : increased effect, aextracellular matrix, bmatrix metalloproteinase, ctissue inhibitor of metalloproteinase, dplasminogen activator inhibitor type 1, eurokinase-plasminogen activator.