Figure 1

Histopathological change in liver (H&E stanining). Photomicrograph of liver section (40 x) for (A) normal hepatocytes; (B) untreated group (negative control) after administration of 250 mg/kg paracetamol showing microvesicular steatosis (arrow) in the liver parenchyma; (C) paracetamol group after administration of 50 mg/kg silybin showing minimal microvesicular steatosis; (D) paracetamol group after administration of 2 mL/kg of synthetic vinegar showing the development of microvesicular steatosis (arrow) in the liver parenchyma; (E) paracetamol group after administration of 0.08 mL/kg of synthetic vinegar with recovery effect of microvesicular steatosis; (F) paracetamol group after administration of 2 mL/kg of pineapple vinegar showing the lesser development of microvesicular steatosis (arrow) in the liver parenchyma; (G) paracetamol group after administration of 0.08 mL/kg of pineapple vinegar with recovery effect of fatty changes. CV is central vain; arrow indicates microvesicular steatosis.