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Figure 4 | Chinese Medicine

Figure 4

From: Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A

Figure 4

Effects of LicA on (A) the LXRE-containing promoter activity of ABCA1 and ABCG1 genes and (B) the T0901317-stimulated mRNA levels of ABCA1 and ABCG1. (A) The activity of ABCA1 LXRE-luciferase or ABCG1 LXRE-luciferase was determined, following treatment with 1 μM T0901317 and 10 μg/mL LicA, in HepG2 cells and normalized to cotransfected β-galactosidase activity. Data were presented as means (SD) from four independent experiments with duplicate determinations. (B) The mRNA levels of ABCA1 and ABCG1 were measured in primary hepatocytes treated with 1 μM T0901317 and 10 μg/mL LicA by qRT-PCR. Data were presented as means (SD) from 4 independent experiments with triplicate determinations. Statistical analysis was performed by one-way ANOVA. P* = P value for Bonferroni correction. DMSO, dimethyl sulfoxide; T1317, T0901317.

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