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Figure 5 | Chinese Medicine

Figure 5

From: Selective inhibition of liver X receptor α-mediated lipogenesis in primary hepatocytes by licochalcone A

Figure 5

Effects of LicA on the recruitments of RNA polymerase II to the LXRE regions of SREBP-1c (A) and ABCA1 (B) genes. After treatment of primary hepatocytes with 1 μM T0901317 and 10 μg/mL LicA, ChIP assays were performed using anti-RNA polymerase II or IgG antibodies. Immunoprecipitated LXRE-containing DNA levels were determined by qRT-PCR and normalized to input DNA. Data were presented as means (SD) from four independent experiments with triplicate determinations. Statistical analysis was performed by one-way ANOVA. P* = P value for Bonferroni correction. DMSO, dimethyl sulfoxide; T1317, T0901317.

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