Fig. 2

Peripheral blood leukocyte and neutrophil count. Total leukocyte count of the peripheral blood samples was obtained using an automated cell counter. Leukocyte differential count was carried out on a minimum of 100 cells. a Peripheral blood leukocyte and neutrophil count after drug administration at different time points. In the G-CSF group, the number of total white blood cells significantly increased on day 4 and then gradually decreased thereafter. In the APS group, total leukocyte count gradually increased. No statistical difference was observed between the APS and G-CSF groups after 7 days (P > 0.05). b With APS and G-CSF administration, the proportion of peripheral blood PMNLs in total white blood cells started to increase, and a significant increase was observed in the APS group on day 14 (vs. the CTX group and G-CSF groups, P < 0.05). However, the percentage of PMNLs in total white blood cells in the G-CSF group was slightly lower than that of the CTX group at each time point (P > 0.05). Data were expressed as means ± SD. Comparison of CTX + APS and CTX + G-CSF groups showed a significant difference (**:P < 0.01, *: P < 0.05). Comparison of CTX + APS group and CTX group showed a significant difference (^ ^: P < 0.01, ^: P < 0.05)