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Fig. 5 | Chinese Medicine

Fig. 5

From: Astragalus polysaccharide promotes the release of mature granulocytes through the L-selectin signaling pathway

Fig. 5

Chemotactic ability of mature BM granulocytes and peripheral blood PMNLs. A micropore membrane was used to assess the chemotactic ability of mature BM granulocytes (a) and blood PMNLs (b). The chemotactic ability of mature BM granulocytes and peripheral blood PMNLs significantly decreased at each time point. In the CTX group, the minimum value was obtained on day 4 (P < 0.001 vs. control group). At each time point thereafter, the values were significantly lower than those of the other treatment groups, and the value of the CTX group was only 50 % of control group on day 14. In the APS group, the minimum value obtained on day 4, before gradually increasing on days 7, 10, and 14. The chemotactic ability of both mature BM granulocytes and peripheral blood PMNLs of the APS group were higher than those of the CTX group (P < 0.01), and the G-CSF group, especially 10 and 14 days after chemotherapy. The maximum value obtained in the CTX group on day 4 was not significantly different with that of the control group. The decrease in values observed on day 7, 10, and 14 was not significant. On day 10 and 14, the chemotactic ability in the G-CSF group was lower than that of the control and APS groups (P < 0.05). Compared with the CTX group, the chemotactic ability of mature BM granulocytes and peripheral blood PMNLs in APS group improved significantly after 7 days. Data were expressed as means ± SD. Comparison of CTX + APS group and CTX + G-CSF group showed a significant difference (**:P < 0.01, *: P < 0.05). Comparison of CTX + APS group and CTX group showed a significant difference (^ ^: P < 0.01, ^: P < 0.05)

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