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Fig. 4 | Chinese Medicine

Fig. 4

From: Panax Notoginseng flower saponins (PNFS) inhibit LPS-stimulated NO overproduction and iNOS gene overexpression via the suppression of TLR4-mediated MAPK/NF-kappa B signaling pathways in RAW264.7 macrophages

Fig. 4

PNFS significantly inhibited the iNOS gene overexpression, but did not affect iNOS enzymatic activity in LPS-stimulated RAW264.7 macrophages. a PNFS inhibited the LPS-stimulated iNOS protein overproduction in RAW264.7 macrophages. b PNFS suppressed the LPS-stimulated iNOS mRNA overexpression in RAW264.7 macrophages. c PNFS did not affect LPS-stimulated iNOS enzymatic activity in Raw264.7 macrophages. Data in Fig. 4a, b and c were all expressed as the mean (SD) of 3 independent experiments. One-Way ANOVA test was used to analyzed the data and the results were F = 1611.288; P < 0.001, F = 414.434; P < 0.001 and F = 110.064; P < 0.001, respectively. Then, data in Fig. 4a, b and c were all counted by SNK and LSD multiple comparisons to determine the statistical difference between two groups. The P values represented the statistical differences between each group and the corresponding positive control (without PNFS and with LPS treated). *** means P < 0.001

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