Table 2 Summary of published clinical trials on combinations of XYS and antidepressants in the treatment of MDD

Wang et al. [9]

CCMD-3

Xiaoyao pill and duloxetine

Duloxetine

N/A

N/A

8

N/A

↑

↑ (CGI)

NS (TESS)

N/A

N/A

Wang et al. [10]

CCMD-3

Xiaoyao pill and doxepin

Fluoxetine

N/A

N/A

6

N/A

NS

NS

NS (TESS)

N/A

↑

Nan et al. [11]

CCMD-2-R

Xiaoyao pill and imipramine

Imipramine

N/A

N/A

8

6

NS

↑ (cure rate)

↓

↓

N/A

Li et al. [12]

CCMD-3

Xiaoyao pill and imipramine

Imipramine

N/A

N/A

8

N/A

NS

NS

↓

N/A

↑

Du et al. [13]

CCMD-3

Xiaoyao pill and fluoxetine

Amitriptyline

N/A

N/A

6

N/A

NS

NS

↓ (TESS)

N/A

↑

Ma [14]

CCMD-3

Xiaoyao pill and citalopram

Citalopram

Random number table

N/A

8

12

NS

NS

↓ (TESS)

↓

N/A

Chen [15]

CCMD-2-R

Xiaoyao pill and amitriptyline

Amitriptyline

N/A

N/A

6

6

↑

↑

↓ (TESS)

↓

N/A

Zhai et al. [16]

CCMD-2-R

Xiaoyao pill and doxepin

Doxepin

N/A

N/A

8

N/A

NS

NS

↓

(TESS)

N/A

N/A

Zhang et al. [17]

CCMD-3

Xiaoyao pill and fluoxetine

Fluoxetine

N/A

N/A

6

N/A

NS

NS

↓ (TESS)

N/A

↑

Zhang et al. [18]

CCMD-2-R

Xiaoyao pill and fluoxetine

fluoxetine

N/A

N/A

3

N/A

N/A

↑ (Zung value)

↓ (TESS)

N/A

N/A

Xia et al. [19]

CCMD-3

Xiaoyao pill and citalopram

Citalopram

N/A

N/A

8

N/A

↑

↑

↓ (TESS)

N/A

N/A

Xiang [20]

CCMD-3

Xiaoyao pill and paroxetine

Paroxetine

N/A

N/A

12

12

N/A

↑ (SDS)

N/A

↓

N/A