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Table 2 Summary of published clinical trials on combinations of XYS and antidepressants in the treatment of MDD

From: Effect of Xiaoyaosan on major depressive disorder

Study ID Sample size Diagnostic criteria Test design Course (weeks) Follow-up (months) Major outcomes
Intervention Control Randomizer Blindness Efficacy by HAMD Clinical efficacy Side effects Relapse Onset time
Wang et al. [9] 120 CCMD-3 Xiaoyao pill and duloxetine Duloxetine N/A N/A 8 N/A ↑ (CGI) NS (TESS) N/A N/A
Wang et al. [10] 68 CCMD-3 Xiaoyao pill and doxepin Fluoxetine N/A N/A 6 N/A NS NS NS (TESS) N/A
Nan et al. [11] 61 CCMD-2-R Xiaoyao pill and imipramine Imipramine N/A N/A 8 6 NS ↑ (cure rate) N/A
Li et al. [12] 60 CCMD-3 Xiaoyao pill and imipramine Imipramine N/A N/A 8 N/A NS NS N/A
Du et al. [13] 150 CCMD-3 Xiaoyao pill and fluoxetine Amitriptyline N/A N/A 6 N/A NS NS ↓ (TESS) N/A
Ma [14] 30 CCMD-3 Xiaoyao pill and citalopram Citalopram Random number table N/A 8 12 NS NS ↓ (TESS) N/A
Chen [15] 61 CCMD-2-R Xiaoyao pill and amitriptyline Amitriptyline N/A N/A 6 6 ↓ (TESS) N/A
Zhai et al. [16] 24 CCMD-2-R Xiaoyao pill and doxepin Doxepin N/A N/A 8 N/A NS NS
(TESS)
N/A N/A
Zhang et al. [17] 50 CCMD-3 Xiaoyao pill and fluoxetine Fluoxetine N/A N/A 6 N/A NS NS ↓ (TESS) N/A
Zhang et al. [18] 50 CCMD-2-R Xiaoyao pill and fluoxetine fluoxetine N/A N/A 3 N/A N/A ↑ (Zung value) ↓ (TESS) N/A N/A
Xia et al. [19] 60 CCMD-3 Xiaoyao pill and citalopram Citalopram N/A N/A 8 N/A ↓ (TESS) N/A N/A
Xiang [20] 76 CCMD-3 Xiaoyao pill and paroxetine Paroxetine N/A N/A 12 12 N/A ↑ (SDS) N/A N/A
  1. CCMD China classification and diagnostic criteria for mental disorder, HAMD Hamilton depression scale, TESS treatment-emergent symptom side effect, SDS self-rating depression scale, CGI clinical global impression, N/A not available, NS no significant difference between intervention and control, ↑ significant increase compared with control, ↓ significant decrease compared with control.